Measurement of the Immunosuppressant Possession Ratio by Transplant Clinical Pharmacists Captures a Non-Adherence Associated With Antibody-Mediated Rejection.
| dc.rights.license | open | en_US |
| dc.contributor.author | CHAMBORD, Jeremy | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation [ImmunoConcept] | |
| dc.contributor.author | CHAUVEAU, Bertrand | |
| hal.structure.identifier | BoRdeaux Institute in onCology [Inserm U1312 - BRIC] | |
| dc.contributor.author | DJABAROUTI, Sarah | |
| dc.contributor.author | VIGNAUD, Jean | |
| dc.contributor.author | TATON, Benjamin | |
| dc.contributor.author | MOREAU, Karine | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation [ImmunoConcept] | |
| dc.contributor.author | VISENTIN, Jonathan | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation [ImmunoConcept] | |
| dc.contributor.author | MERVILLE, Pierre | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | XUEREB, Fabien | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation [ImmunoConcept] | |
| dc.contributor.author | COUZI, Lionel | |
| dc.date.accessioned | 2024-03-11T15:29:32Z | |
| dc.date.available | 2024-03-11T15:29:32Z | |
| dc.date.issued | 2023-01-01 | |
| dc.identifier.issn | 1432-2277 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/188690 | |
| dc.description.abstractEn | Our objective was to calculate an immunosuppressant possession ratio (IPR) to diagnose non-adherence at the time of antibody-mediated rejection (ABMR). IPR was defined as the ratio of number of pills collected at the pharmacy to the number of pills prescribed over a defined period. In a first cohort of 91 kidney transplant recipients (KTRs), those with an IPR 30% than patients with an IPR = 100% (66.7% vs. 29.4%, = 0.05). In a case-control study, 26 KTRs with ABMR had lower 6 months IPRs than 26 controls (76% vs. 99%, < 0.001). In KTRs with ABMR, non-adherence was more often diagnosed by a 6 months IPR < 90% than by clinical suspicion (73.1% vs 30.8%, = 0.02). In the multivariable analysis, only DSA and 6 months IPR < 90% were independently associated with ABMR, whereas clinical suspicion was not (odds ratio, 4.73; 95% CI, 1.17-21.88; = 0.03; and odds ratio, 6.34; 95% CI, 1.73-25.59; = 0.007, respectively). In summary, IPR < 90% is a quantifiable tool to measure immunosuppressant non-adherence. It is better associated with ABMR than clinical suspicion of non-adherence. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject | article clinique | |
| dc.subject.en | Humans | |
| dc.subject.en | Immunosuppressive Agents | |
| dc.subject.en | Case-Control Studies | |
| dc.subject.en | Pharmacists | |
| dc.subject.en | Kidney Transplantation | |
| dc.subject.en | Antibodies | |
| dc.subject.en | Graft Rejection | |
| dc.subject.en | Isoantibodies | |
| dc.title.en | Measurement of the Immunosuppressant Possession Ratio by Transplant Clinical Pharmacists Captures a Non-Adherence Associated With Antibody-Mediated Rejection. | |
| dc.title.alternative | Transpl Int | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3389/ti.2023.11962 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie | en_US |
| dc.identifier.pubmed | 38089004 | en_US |
| bordeaux.journal | Transplant International | en_US |
| bordeaux.page | 11962 | en_US |
| bordeaux.volume | 36 | en_US |
| bordeaux.hal.laboratories | Biologie des maladies cardiovasculaires (BMC) - UMR 1034 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-04500021 | |
| hal.version | 1 | |
| hal.date.transferred | 2024-03-11T15:29:34Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Transplant%20International&rft.date=2023-01-01&rft.volume=36&rft.spage=11962&rft.epage=11962&rft.eissn=1432-2277&rft.issn=1432-2277&rft.au=CHAMBORD,%20Jeremy&CHAUVEAU,%20Bertrand&DJABAROUTI,%20Sarah&VIGNAUD,%20Jean&TATON,%20Benjamin&rft.genre=article |
