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dc.rights.licenseopenen_US
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorBEURTON, Antoine
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorMICHOT, Maxime
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorHERION, Francois-Xavier
dc.contributor.authorRIENZO, Mario
dc.contributor.authorODDOS, Claire
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorCOUFFINHAL, Thierry
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorIMBAULT, Julien
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorOUATTARA, Alexandre
dc.date.accessioned2024-03-11T14:41:06Z
dc.date.available2024-03-11T14:41:06Z
dc.date.issued2024-03-01
dc.identifier.issn1538-943Xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/188686
dc.description.abstractEnPeripheral venoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly being used in patients suffering from refractory cardiogenic shock (CS). Although considered life-saving, peripheral VA-ECMO may also be responsible for intracardiac hemodynamic changes, including left ventricular overload and dysfunction. Venoarterial extracorporeal membrane oxygenation may also increase myocardial wall stress and stroke work, possibly affecting the cellular cardioprotective and apoptosis signaling pathways, and thus the infarct size. To test this hypothesis, we investigated the effects of increasing the peripheral VA-ECMO blood flow (25-100% of the baseline cardiac output) on systemic and cardiac hemodynamics in a closed-chest CS model. Upon completion of the experiment, the hearts were removed for assessment of infarct size, histology, apoptosis measurements, and phosphorylation statuses of p38 and protein Kinase B (Akt), and extracellular signal-regulated kinase mitogen-activated protein kinases (ERK-MAPK). Peripheral VA-ECMO restored systemic perfusion but induced a significant and blood flow-dependent increase in left ventricular preload and afterload. Venoarterial extracorporeal membrane oxygenation did not affect infarct size but significantly decreased p38-MAPK phosphorylation and cardiac myocyte apoptosis in the border zone.
dc.language.isoENen_US
dc.subjectarticle clinique
dc.subject.enHumans
dc.subject.enShock
dc.subject.enCardiogenic
dc.subject.enExtracorporeal Membrane Oxygenation
dc.subject.enHemodynamics
dc.subject.enMyocardium
dc.subject.enSignal Transduction
dc.title.enSystemic Hemodynamics, Cardiac Mechanics, and Signaling Pathways Induced by Extracorporeal Membrane Oxygenation in a Cardiogenic Shock Model.
dc.title.alternativeASAIO Jen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/MAT.0000000000002139en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
dc.identifier.pubmed38261663en_US
bordeaux.journalASAIO Journalen_US
bordeaux.page177-184en_US
bordeaux.volume70en_US
bordeaux.hal.laboratoriesBiologie des maladies cardiovasculaires (BMC) - UMR 1034en_US
bordeaux.issue3en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04590088
hal.version1
hal.date.transferred2024-03-11T14:41:08Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=ASAIO%20Journal&rft.date=2024-03-01&rft.volume=70&rft.issue=3&rft.spage=177-184&rft.epage=177-184&rft.eissn=1538-943X&rft.issn=1538-943X&rft.au=BEURTON,%20Antoine&MICHOT,%20Maxime&HERION,%20Francois-Xavier&RIENZO,%20Mario&ODDOS,%20Claire&rft.genre=article


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