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Healthcare-associated infections in patients with severe COVID-19 supported with extracorporeal membrane oxygenation: a nationwide cohort study

dc.rights.licenseopenen_US
hal.structure.identifierCentre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
hal.structure.identifierCentre d'Investigation Clinique [Rennes] [CIC]
hal.structure.identifierNutrition, Métabolismes et Cancer [NuMeCan]
dc.contributor.authorNESSELER, Nicolas
hal.structure.identifierInstitut de recherche en santé, environnement et travail [Irset]
hal.structure.identifierCentre d'Investigation Clinique [Rennes] [CIC]
hal.structure.identifierCentre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
dc.contributor.authorMANSOUR, Alexandre
hal.structure.identifierUnité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases [ICAN]
dc.contributor.authorSCHMIDT, Matthieu
hal.structure.identifierLaboratoire de Recherche Vasculaire Translationnelle [LVTS (UMR_S_1148 / U1148)]
dc.contributor.authorPARA, Marylou
hal.structure.identifierAssistance Publique - Hôpitaux de Marseille [APHM]
dc.contributor.authorPORTO, Alizée
hal.structure.identifierNanomédecine Régénérative [NanoRegMed]
dc.contributor.authorFALCOZ, Pierre-Emmanuel
hal.structure.identifierInstitut Mondor de Recherche Biomédicale [IMRB]
dc.contributor.authorMONGARDON, Nicolas
hal.structure.identifierCentre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
hal.structure.identifierCentre d'Investigation Clinique [Rennes] [CIC]
dc.contributor.authorFOUGEROU, Claire
hal.structure.identifierCase Western Reserve University [Cleveland]
dc.contributor.authorROSS, James
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorBEURTON, Antoine
hal.structure.identifierCentre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
dc.contributor.authorGAIDE-CHEVRONNAY, Lucie
dc.contributor.authorGUINOT, Pierre-Grégoire
hal.structure.identifierUnité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases [ICAN]
dc.contributor.authorLEBRETON, Guillaume
hal.structure.identifierCentre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
hal.structure.identifierLaboratoire Traitement du Signal et de l'Image [LTSI]
dc.contributor.authorFLECHER, Erwan
hal.structure.identifierRécepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011 [RNMCD]
dc.contributor.authorVINCENTELLI, André
hal.structure.identifierCentre hospitalier de Saint-Brieuc [Hôpital Yves Le Foll] [CH Saint-Brieuc]
dc.contributor.authorMASSART, Nicolas
dc.contributor.authorFOUQUET, Olivier
dc.contributor.authorPIERROT, Marc
dc.contributor.authorCHOCRON, Sidney
dc.contributor.authorFLICOTEAUX, Guillaume
dc.contributor.authorMAURIAT, Philippe
dc.contributor.authorOUATTARA, Alexandre
dc.contributor.authorROZE, Hadrien
dc.contributor.authorHUET, Olivier
dc.contributor.authorFISCHER, Marc-Olivier
dc.contributor.authorBELLAÏCHE, Raphel
dc.contributor.authorCONSTANT, Ophélie
dc.contributor.authorDE ROUX, Quentin
dc.contributor.authorANDRÉ, L.
dc.contributor.authorMEFFERT, Arnaud
dc.contributor.authorMERLE, Jean-Claude
dc.contributor.authorPICARD, Lucile
dc.contributor.authorSKRIPKINA, Elena
dc.contributor.authorFOLLIGUET, Thierry
dc.contributor.authorFIORE, Antonio
dc.contributor.authorD’OSTREVY, Nicolas
dc.contributor.authorMORGAN, Marie-Catherine
dc.contributor.authorNGUYEN, Maxime
dc.contributor.authorTERZI, Nicolas
dc.contributor.authorCOLIN, Gwenhaël
dc.contributor.authorFABRE, Olivier
dc.contributor.authorASTANEH, Arash
dc.contributor.authorISSARD, Justin
dc.contributor.authorFADEL, Elie
dc.contributor.authorFABRE, Dominique
dc.contributor.authorGUIHAIRE, Julien
dc.contributor.authorION, Iolande
dc.contributor.authorMENAGER, Jean Baptiste
dc.contributor.authorMITILIAN, Delphine
dc.contributor.authorMERCIER, Olaf
dc.contributor.authorSTEPHAN, François
dc.contributor.authorTHES, Jacques
dc.contributor.authorJOUAN, Jerôme
dc.contributor.authorDUBURCQ, Thibault
dc.contributor.authorLOOBUYCK, Valentin
dc.contributor.authorMOUSSA, Mouhammed
dc.contributor.authorMANGANIELLO, Sabrina
dc.contributor.authorMUGNIER, Agnes
dc.contributor.authorROUSSE, Natacha
dc.contributor.authorDESEBBE, Olivier
dc.contributor.authorFELLAHI, Jean-Luc
dc.contributor.authorHENAINE, Roland
dc.contributor.authorPOZZI, Matteo
dc.contributor.authorRIAD, Zakaria
dc.contributor.authorGUERVILLY, Christophe
dc.contributor.authorHRAIECH, Sami
dc.contributor.authorPAPAZIAN, Laurent
dc.contributor.authorCASTANIER, Matthias
dc.contributor.authorCHANAVAZ, Charles
dc.contributor.authorCADOZ, Cyril
dc.contributor.authorGETTE, Sebastien
dc.contributor.authorLOUIS, Guillaume
dc.contributor.authorPORTOCARRERO, Erick
dc.contributor.authorGAUDARD, Philippe
dc.contributor.authorBRINI, Kais
dc.contributor.authorBISCHOFF, Nicolas
dc.contributor.authorKIMMOUN, Antoine
dc.contributor.authorLEVY, Bruno
dc.contributor.authorPEREZ, Pierre
dc.contributor.authorBOURDIOL, Alexandre
dc.contributor.authorHOURMANT, Yannick
dc.contributor.authorMAHÉ, Pierre-Joachim
dc.contributor.authorROZEC, Bertrand
dc.contributor.authorVOURC’H, Mickaël
dc.contributor.authorAUBERT, Stéphane
dc.contributor.authorBAZALGETTE, Florian
dc.contributor.authorROGER, Claire
dc.contributor.authorJAQUET, Pierre
dc.contributor.authorLORTAT-JACOB, Brice
dc.contributor.authorMORDANT, Pierre
dc.contributor.authorNATAF, Patrick
dc.contributor.authorPATRIER, Juliette
dc.contributor.authorPROVENCHERE, Sophie
dc.contributor.authorROUÉ, Morgan
dc.contributor.authorSONNEVILLE, Romain
dc.contributor.authorTRAN-DINH, Alexy
dc.contributor.authorWICKY, Paul-Henri
dc.contributor.authorAL ZREIBI, Charles
dc.contributor.authorCHOLLEY, Bernard
dc.contributor.authorGUYONVARCH, Yannis
dc.contributor.authorHAMADA, Sophie
dc.contributor.authorBARBANTI, Claudio
dc.contributor.authorBERTIER, Astrid
dc.contributor.authorHARROIS, Anatole
dc.contributor.authorMATIELLO, Jordi
dc.contributor.authorKERFORNE, Thomas
dc.contributor.authorLACROIX, Corentin
dc.contributor.authorBRECHOT, Nicolas
dc.contributor.authorCOMBES, Alain
dc.contributor.authorCHOMMELOUX, Juliette
dc.contributor.authorD’ALESSANDRO, Cosimo
dc.contributor.authorDEMONDION, Pierre
dc.contributor.authorDEMOULE, Alexandre
dc.contributor.authorDRES, Martin
dc.contributor.authorFADEL, Guillaume
dc.contributor.authorFARTOUKH, Muriel
dc.contributor.authorHEKIMIAN, Guillaume
dc.contributor.authorJUVIN, Charles
dc.contributor.authorLEPRINCE, Pascal
dc.contributor.authorLEVY, David
dc.contributor.authorLUYT, Charles Edouard
dc.contributor.authorSCHOELL, Thibaut
dc.contributor.authorFILLÂTRE, Pierre
dc.contributor.authorJONAS, Maud
dc.contributor.authorALLOU, Nicolas
dc.contributor.authorMUCCIO, Salvatore
dc.contributor.authorDI PERNA, Dario
dc.contributor.authorRUGGIERI, Vito-Giovanni
dc.contributor.authorMOURVILLIER, Bruno
dc.contributor.authorANSELMI, Amedeo
dc.contributor.authorBOUNADER, Karl
dc.contributor.authorLAUNEY, Yoann
dc.contributor.authorLEBOUVIER, Thomas
dc.contributor.authorPARASIDO, Alessandro
dc.contributor.authorREIZINE, Florian
dc.contributor.authorESVAN, Maxime
dc.contributor.authorSEGUIN, Philippe
dc.contributor.authorBESNIER, Emmanuel
dc.contributor.authorCARPENTIER, Dorothée
dc.contributor.authorCLAVIER, Thomas
dc.contributor.authorOLLAND, Anne
dc.contributor.authorVILLARD, Marion
dc.contributor.authorBOUNES, Fanny
dc.contributor.authorLABASTE, François
dc.contributor.authorMINVILLE, Vincent
dc.contributor.authorGUILLON, Antoine
dc.contributor.authorFEDUN, Yannick
dc.date.accessioned2024-03-11T14:28:35Z
dc.date.available2024-03-11T14:28:35Z
dc.date.issued2024-02-20
dc.identifier.issn1364-8535en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/188685
dc.description.abstractEnBackground Both critically ill patients with coronavirus disease 2019 (COVID-19) and patients receiving extracorporeal membrane oxygenation (ECMO) support exhibit a high incidence of healthcare-associated infections (HAI). However, data on incidence, microbiology, resistance patterns, and the impact of HAI on outcomes in patients receiving ECMO for severe COVID-19 remain limited. We aimed to report HAI incidence and microbiology in patients receiving ECMO for severe COVID-19 and to evaluate the impact of ECMO-associated infections (ECMO-AI) on in-hospital mortality. Methods For this study, we analyzed data from 701 patients included in the ECMOSARS registry which included COVID-19 patients supported by ECMO in France. Results Among 602 analyzed patients for whom HAI and hospital mortality data were available, 214 (36%) had ECMO-AI, resulting in an incidence rate of 27 ECMO-AI per 1000 ECMO days at risk. Of these, 154 patients had bloodstream infection (BSI) and 117 patients had ventilator-associated pneumonia (VAP). The responsible microorganisms were Enterobacteriaceae (34% for BSI and 48% for VAP), Enterococcus species (25% and 6%, respectively) and non-fermenting Gram-negative bacilli (13% and 20%, respectively). Fungal infections were also observed (10% for BSI and 3% for VAP), as were multidrug-resistant organisms (21% and 15%, respectively). Using a Cox multistate model, ECMO-AI were not found associated with hospital death (HR = 1.00 95% CI [0.79–1.26], p = 0.986). Conclusions In a nationwide cohort of COVID-19 patients receiving ECMO support, we observed a high incidence of ECMO-AI. ECMO-AI were not found associated with hospital death. Trial registration number NCT04397588 (May 21, 2020).
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enBloodstream infections
dc.subject.enECLS
dc.subject.enNosocomial infections
dc.subject.enSARS-CoV 2
dc.subject.enVentilator-associated pneumonia
dc.subject.meshHumans
dc.subject.meshCOVID-19
dc.subject.meshCohort Studies
dc.subject.meshExtracorporeal Membrane Oxygenation
dc.subject.meshCross Infection
dc.subject.meshPneumonia, Ventilator-Associated
dc.subject.meshSepsis
dc.subject.meshDelivery of Health Care
dc.subject.meshRetrospective Studies
dc.title.enHealthcare-associated infections in patients with severe COVID-19 supported with extracorporeal membrane oxygenation: a nationwide cohort study
dc.typeArticle de revueen_US
dc.identifier.doi10.1186/s13054-024-04832-3en_US
dc.subject.halSciences du Vivant [q-bio]/Ingénierie biomédicaleen_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
dc.identifier.pubmed38374103en_US
bordeaux.journalCritical Careen_US
bordeaux.page54en_US
bordeaux.volume28en_US
bordeaux.hal.laboratoriesBiologie des maladies cardiovasculaires (BMC) - UMR 1034en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-04477794
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccCC BYen_US
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