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The skin autofluorescence may help to select patients with Type 2 diabetes candidates for screening to revascularization procedures
MOHAMMEDI, Kamel
Bordeaux population health [BPH]
Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
< Leer menos
Bordeaux population health [BPH]
Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
Idioma
EN
Article de revue
Este ítem está publicado en
Cardiovascular Diabetology. 2024-01-13, vol. 23, n° 1, p. 32
Resumen en inglés
Chen et al. recently related the skin autofluorescence (SAF) of Advanced Glycation End-products to subclinical cardiovascular disease in the 3001 participants from the general population (Rotterdam study), with a particularly ...Leer más >
Chen et al. recently related the skin autofluorescence (SAF) of Advanced Glycation End-products to subclinical cardiovascular disease in the 3001 participants from the general population (Rotterdam study), with a particularly close relationship for the 413 subjects with diabetes. Because conventional vascular risk factors do not capture the risk in diabetes very well, this relationship may help to select high-risk individuals for the screening of silent myocardial ischemia, which has yet to prove its benefit in randomized controlled trials. Among 477 patients with uncontrolled and/or complicated Type 2 Diabetes, we measured the SAF ten years ago, and we registered new revascularizations during a 54-months follow-up. The patients with SAF > 2.6 Arbitrary units (AUs), the median population value, experienced more revascularizations of the coronary (17/24) and lower-limb arteries (13/17) than patients with a lower SAF, adjusted for age, sex, diabetes duration, vascular complications, and smoking habits: HR 2.17 (95% CI: 1.05-4.48), p = 0.035. The SAF has already been reported to predict cardiovascular events in three cohorts of people with diabetes. We suggest that its measurement may help to improve the performance of the screening before vascular explorations and revascularizations.< Leer menos
Palabras clave en inglés
Humans
Diabetes Mellitus
Type 2
Skin
Risk Factors
Glycation End Products
Advanced
Smoking