Afficher la notice abrégée

Effects of socioeconomic status on excess mortality in patients with multiple sclerosis in France: A retrospective observational cohort study

dc.rights.licenseopenen_US
dc.contributor.authorWILSON, Sarah
dc.contributor.authorCALOCER, Floriane
dc.contributor.authorROLLOT, Fabien
dc.contributor.authorFAUVERNIER, Mathieu
dc.contributor.authorREMONTET, Laurent
dc.contributor.authorTRON, Laure
dc.contributor.authorVUKUSIC, Sandra
dc.contributor.authorLE PAGE, Emmanuelle
dc.contributor.authorDEBOUVERIE, Marc
dc.contributor.authorCIRON, Jonathan
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorRUET, Aurélie
dc.contributor.authorDE SEZE, Jerome
dc.contributor.authorZEPHIR, Helene
dc.contributor.authorMOREAU, Thibault
dc.contributor.authorLEBRUN-FRENAY, Christine
dc.contributor.authorLAPLAUD, David-Axel
dc.contributor.authorCLAVELOU, Pierre
dc.contributor.authorLABAUGE, Pierre
dc.contributor.authorBERGER, Eric
dc.contributor.authorPELLETIER, Jean
dc.contributor.authorHEINZLEF, Olivier
dc.contributor.authorTHOUVENOT, Eric
dc.contributor.authorCAMDESSANCHE, Jean-Philippe
dc.contributor.authorLERAY, Emmanuelle
dc.contributor.authorDEJARDIN, Olivier
dc.contributor.authorDEFER, Gilles
dc.date.accessioned2024-01-26T10:57:15Z
dc.date.available2024-01-26T10:57:15Z
dc.date.issued2023
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/187550
dc.description.abstractEnBackground: The effects of socio-economic status on mortality in patients with multiple sclerosis is not well known. The objective was to examine mortality due to multiple sclerosis according to socio-economic status. Methods: A retrospective observational cohort design was used with recruitment from 18 French multiple sclerosis expert centers participating in the Observatoire Français de la Sclérose en Plaques. All patients lived in metropolitan France and had a definite or probable diagnosis of multiple sclerosis according to either Poser or McDonald criteria with an onset of disease between 1960 and 2015. Initial phenotype was either relapsing-onset or primary progressive onset. Vital status was updated on January 1st 2016. Socio-economic status was measured by an ecological index, the European Deprivation Index and was attributed to each patient according to their home address. Excess death rates were studied according to socio-economic status using additive excess hazard models with multidimensional penalised splines. The initial hypothesis was a potential socio-economic gradient in excess mortality. Findings: A total of 34,169 multiple sclerosis patients were included (88% relapsing onset (n = 30,083), 12% progressive onset (n = 4086)), female/male sex ratio 2.7 for relapsing-onset and 1.3 for progressive-onset). Mean age at disease onset was 31.6 (SD = 9.8) for relapsing-onset and 42.7 (SD = 10.8) for progressive-onset. At the end of follow-up, 1849 patients had died (4.4% for relapsing-onset (n = 1311) and 13.2% for progressive-onset (n = 538)). A socio-economic gradient was found for relapsing-onset patients; more deprived patients had a greater excess death rate. At thirty years of disease duration and a year of onset of symptoms of 1980, survival probability difference (or deprivation gap) between less deprived relapsing-onset patients (EDI = −6) and more deprived relapsing-onset patients (EDI = 12) was 16.6% (95% confidence interval (CI) [10.3%–22.9%]) for men and 12.3% (95%CI [7.6%–17.0%]) for women. No clear socio-economic mortality gradient was found in progressive-onset patients. Interpretation: Socio-economic status was associated with mortality due to multiple sclerosis in relapsing-onset patients. Improvements in overall care of more socio-economically deprived patients with multiple sclerosis could help reduce these socio-economic inequalities in multiple sclerosis-related mortality. Funding: This study was funded by the ARSEP foundation “Fondation pour l'aide à la recherche sur la Sclérose en Plaques” (Grant Reference Number 1122). Data collection has been supported by a grant provided by the French State and handled by the “Agence Nationale de la Recherche,” within the framework of the “Investments for the Future” programme, under the reference ANR-10-COHO-002, Observatoire Français de la Sclérose en Plaques (OFSEP). © 2022 The Author(s)
dc.description.sponsorshipObservatoire Français de la Sclérose en Plaquesen_US
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enMultiple sclerosis
dc.subject.enExcess mortality
dc.subject.enNet survival
dc.subject.enSocio-economic status
dc.subject.enFlexible model
dc.subject.enObservational cohort study
dc.title.enEffects of socioeconomic status on excess mortality in patients with multiple sclerosis in France: A retrospective observational cohort study
dc.title.alternativeLancet Reg Health Euren_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.lanepe.2022.100542en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed36426377en_US
bordeaux.journalThe Lancet Regional Health - Europeen_US
bordeaux.volume24en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamRelations glie-neuroneen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation pour l'Aide à la Recherche sur la Sclérose en Plaquesen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccCC BY-NC-NDen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=The%20Lancet%20Regional%20Health%20-%20Europe&rft.date=2023&rft.volume=24&rft.au=WILSON,%20Sarah&CALOCER,%20Floriane&ROLLOT,%20Fabien&FAUVERNIER,%20Mathieu&REMONTET,%20Laurent&rft.genre=article


Fichier(s) constituant ce document

Thumbnail
Nom:
MAGENDIE_LancetRegHealthEur_20 ...
Taille:
294.1Ko
Format:
PDF
Voir/Ouvrir
Thumbnail
Nom:
license_rdf
Taille:
811octets
Format:
application/rdf+xml
Voir/Ouvrir

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée