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Childhood maltreatment contributes to the medical morbidity of individuals with bipolar disorders
dc.rights.license | open | en_US |
hal.structure.identifier | Fondation FondaMental [Créteil] | |
hal.structure.identifier | IMRB - "Neuropsychiatrie translationnelle" [Créteil] [U955 Inserm - UPEC] | |
dc.contributor.author | GODIN, Ophelia | |
hal.structure.identifier | Fondation FondaMental [Créteil] | |
hal.structure.identifier | IMRB - "Neuropsychiatrie translationnelle" [Créteil] [U955 Inserm - UPEC] | |
hal.structure.identifier | Hôpital Henri Mondor | |
dc.contributor.author | LEBOYER, Marion | |
hal.structure.identifier | Hôpitaux Universitaire Saint-Louis, Lariboisière, Fernand-Widal | |
hal.structure.identifier | Optimisation thérapeutique en Neuropsychopharmacologie [OPTeN (UMR_S 1144 / U1144)] | |
dc.contributor.author | GRILLAULT LAROCHE, Diane | |
hal.structure.identifier | Fondation FondaMental [Créteil] | |
hal.structure.identifier | Centre Hospitalier Princesse Grace | |
dc.contributor.author | AUBIN, Valerie | |
hal.structure.identifier | Institut de Neurosciences de la Timone [INT] | |
hal.structure.identifier | Fondation FondaMental [Créteil] | |
hal.structure.identifier | Assistance Publique - Hôpitaux de Marseille [APHM] | |
dc.contributor.author | BELZEAUX, Raoul | |
hal.structure.identifier | Centre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier] | |
hal.structure.identifier | Fondation FondaMental [Créteil] | |
hal.structure.identifier | Institut de Génomique Fonctionnelle [IGF] | |
dc.contributor.author | COURTET, Philippe | |
hal.structure.identifier | Hôpital Louis Mourier - AP-HP [Colombes] | |
hal.structure.identifier | Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm] | |
hal.structure.identifier | Fondation FondaMental [Créteil] | |
dc.contributor.author | DUBERTRET, Caroline | |
hal.structure.identifier | Centre hospitalier Charles Perrens [Bordeaux] | |
hal.structure.identifier | Fondation FondaMental [Créteil] | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | GARD, Sebastien | |
hal.structure.identifier | Fondation FondaMental [Créteil] | |
hal.structure.identifier | Centre d'Investigation Clinique de Besançon [Inserm CIC 1431] | |
hal.structure.identifier | Université Bourgogne Franche-Comté [COMUE] [UBFC] | |
dc.contributor.author | HAFFEN, Emmanuel | |
hal.structure.identifier | Centre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier] | |
hal.structure.identifier | Fondation FondaMental [Créteil] | |
hal.structure.identifier | Institut de Génomique Fonctionnelle [IGF] | |
dc.contributor.author | OLIE, Emilie | |
hal.structure.identifier | Fondation FondaMental [Créteil] | |
hal.structure.identifier | Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA] | |
hal.structure.identifier | [GIN] Grenoble Institut des Neurosciences [GIN] | |
dc.contributor.author | POLOSAN, Mircea | |
hal.structure.identifier | Centre Hospitalier de Versailles André Mignot [CHV] | |
hal.structure.identifier | Fondation FondaMental [Créteil] | |
hal.structure.identifier | Centre de recherche en épidémiologie et santé des populations [CESP] | |
dc.contributor.author | ROUX, Paul | |
hal.structure.identifier | Fondation FondaMental [Créteil] | |
hal.structure.identifier | CHU Clermont-Ferrand | |
hal.structure.identifier | Université Clermont Auvergne [UCA] | |
dc.contributor.author | SAMALIN, Ludovic | |
hal.structure.identifier | Centre Psychothérapique de Nancy [Laxou] [CPN] | |
hal.structure.identifier | Fondation FondaMental [Créteil] | |
hal.structure.identifier | Imagerie Adaptative Diagnostique et Interventionnelle [IADI] | |
dc.contributor.author | SCHWAN, Raymund | |
hal.structure.identifier | Hôpital Lariboisière-Fernand-Widal [APHP] | |
hal.structure.identifier | Optimisation thérapeutique en Neuropsychopharmacologie [OPTeN (UMR_S 1144 / U1144)] | |
hal.structure.identifier | Fondation FondaMental [Créteil] | |
dc.contributor.author | BELLIVIER, Frank | |
hal.structure.identifier | Fondation FondaMental [Créteil] | |
hal.structure.identifier | Hôpital Lariboisière-Fernand-Widal [APHP] | |
hal.structure.identifier | Optimisation thérapeutique en Neuropsychopharmacologie [OPTeN (UMR_S 1144 / U1144)] | |
dc.contributor.author | ETAIN, Bruno | |
dc.date.accessioned | 2024-01-11T13:22:56Z | |
dc.date.available | 2024-01-11T13:22:56Z | |
dc.date.issued | 2023-11 | |
dc.identifier.issn | 0033-2917 | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/187059 | |
dc.description.abstractEn | Background: Individuals with bipolar disorders (BD) are at risk of premature death, mainly due to medical comorbidities. Childhood maltreatment might contribute to this medical morbidity, which remains underexplored in the literature.Methods: We assessed 2891 outpatients with BD (according to DSM-IV criteria). Childhood maltreatment was assessed using the Childhood Trauma Questionnaire. Lifetime diagnoses for medical disorders were retrospectively assessed using a systematic interview and checked against medical notes. Medical morbidity was defined by the sum of medical disorders. We investigated associations between childhood maltreatment (neglect and abuse) and medical morbidity while adjusting for potential confounders.Results: One quarter of individuals had no medical comorbidities, while almost half of them had at least two. Multivariable regression showed that childhood maltreatment (mainly abuse, but also sexual abuse) was associated with a higher medical morbidity. Medical morbidity was also associated with sex, age, body mass index, sleep disturbances, lifetime anxiety disorders and lifetime density of mood episodes. Childhood maltreatment was associated with an increased prevalence of four (i.e. migraine/headache, drug eruption, duodenal ulcer, and thyroid diseases) of the fifteen most frequent medical disorders, however with no difference in terms of age at onset.Conclusions: This large cross-sectional study confirmed a high medical morbidity in BD and its association with childhood maltreatment. The assessment of childhood maltreatment in individuals with BD should be systematically included in routine care and the potential impact on physical health of psycho-social interventions targeting childhood maltreatment and its consequences should be evaluated. | |
dc.description.sponsorship | Sorbonne Universités à Paris pour l'Enseignement et la Recherche | en_US |
dc.description.sponsorship | FondaMental-Cohortes - ANR-10-COHO-0010 | en_US |
dc.language.iso | EN | en_US |
dc.subject.en | Bipolar disorders | |
dc.subject.en | childhood maltreatment | |
dc.subject.en | health | |
dc.subject.en | medical comorbidities | |
dc.subject.en | morbidity | |
dc.title.en | Childhood maltreatment contributes to the medical morbidity of individuals with bipolar disorders | |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1017/S0033291723000922 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Psychiatrie et santé mentale | en_US |
dc.identifier.pubmed | 37185275 | en_US |
bordeaux.journal | Psychological Medicine | en_US |
bordeaux.page | 7341-7349 | en_US |
bordeaux.volume | 53 | en_US |
bordeaux.hal.laboratories | NutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
bordeaux.issue | 15 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | Bordeaux INP | en_US |
bordeaux.institution | INRAE | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
bordeaux.identifier.funderID | Fondation FondaMental | en_US |
bordeaux.import.source | hal | |
hal.identifier | hal-04118309 | |
hal.version | 1 | |
hal.popular | non | en_US |
hal.audience | Internationale | en_US |
hal.export | false | |
workflow.import.source | hal | |
dc.rights.cc | Pas de Licence CC | en_US |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Psychological%20Medicine&rft.date=2023-11&rft.volume=53&rft.issue=15&rft.spage=7341-7349&rft.epage=7341-7349&rft.eissn=0033-2917&rft.issn=0033-2917&rft.au=GODIN,%20Ophelia&LEBOYER,%20Marion&GRILLAULT%20LAROCHE,%20Diane&AUBIN,%20Valerie&BELZEAUX,%20Raoul&rft.genre=article |
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