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Quantitative assessment of hippocampal network dynamics by combining Voltage Sensitive Dye Imaging and Optimal Transportation Theory

hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorCOLAVITA, Michelangelo
hal.structure.identifierModeling Enablers for Multi-PHysics and InteractionS [MEMPHIS]
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierÉquipe Calcul scientifique et Modélisation
dc.contributor.authorBOUHARGUANE, Afaf
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierModeling Enablers for Multi-PHysics and InteractionS [MEMPHIS]
hal.structure.identifierÉquipe Calcul scientifique et Modélisation
dc.contributor.authorVALENTI, Andrea
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorTERRAL, Geoffrey
hal.structure.identifierUniversité de Bordeaux [UB]
dc.contributor.authorSHERWOOD, Mark
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorLEMERCIER, Clement
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorGIBERGUES, Fabien
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorDOUBECK, Marion
hal.structure.identifierUniversità degli studi di Catania = University of Catania [Unict]
dc.contributor.authorDRAGO, Filippo
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMARSICANO, Giovanni
hal.structure.identifierModeling Enablers for Multi-PHysics and InteractionS [MEMPHIS]
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorIOLLO, Angelo
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMASSA, Federico
dc.date.issued2023-09-26
dc.description.abstractEnFor many years, voltage sensitive dye imaging (VSDI) has enabled the fruitful analysis of neuronal transmission by monitoring the spreading of neuronal signals. Although useful, the display of diffusion of neuronal depolarization provides insufficient information in the quest for a greater understanding of neuronal computation in brain function. Here, we propose the optimal mass transportation theory as a model to describe the dynamics of neuronal activity. More precisely, we use the solution of an -Monge–Kantorovich problem to model VSDI data, to extract the velocity and overall orientation of depolarization spreading in anatomically defined brain areas. The main advantage of this approach over earlier models (e.g. optical flow) is that the solution does not rely on intrinsic approximations or on additional arbitrary parameters, as shown from simple signal propagation examples. As proof of concept application of our model, we found that in the mouse hippocampal CA1 network, increasing Schaffers collaterals stimulation intensity leads to an increased VSDI-recorded depolarization associated with dramatic decreases in velocity and divergence of signal spreading. In addition, the pharmacological activation of cannabinoid type 1 receptors (CB1) leads to slight but significant decreases in neuronal depolarization and velocity of signal spreading in a region-specific manner within the CA1, indicating the reliability of the approach to identify subtle changes in circuit activity. Overall, our study introduces a novel approach for the analysis of optical imaging data, potentially highlighting new region-specific features of neuronal networks dynamics.
dc.language.isoen
dc.publisherSociété de Mathématiques Appliquées et Industrielles (SMAI)
dc.title.enQuantitative assessment of hippocampal network dynamics by combining Voltage Sensitive Dye Imaging and Optimal Transportation Theory
dc.typeArticle de revue
dc.identifier.doi10.5802/msia.34
dc.subject.halMathématiques [math]
dc.subject.halSciences du Vivant [q-bio]
bordeaux.journalMathematicS In Action
bordeaux.page117-134
bordeaux.volume12
bordeaux.issue1
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionINSERM
bordeaux.peerReviewedoui
hal.identifierhal-04375664
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-04375664v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=MathematicS%20In%20Action&rft.date=2023-09-26&rft.volume=12&rft.issue=1&rft.spage=117-134&rft.epage=117-134&rft.au=COLAVITA,%20Michelangelo&BOUHARGUANE,%20Afaf&VALENTI,%20Andrea&TERRAL,%20Geoffrey&SHERWOOD,%20Mark&rft.genre=article


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