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dc.rights.licenseopenen_US
dc.contributor.authorCICINELLI, Maria Vittoria
dc.contributor.authorGEROSOLIMA, Claudia
dc.contributor.authorSCANDALE, Pierluigi
dc.contributor.authorTOUHAMI, Sarah
dc.contributor.authorPOHLMANN, Dominika
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGIOCANTI, Audrey
dc.contributor.authorROSENBLATT, Amir
dc.contributor.authorLOEWENSTEIN, Anat
dc.contributor.authorBANDELLO, Francesco
dc.contributor.authorMISEROCCHI, Elisabetta
dc.date.accessioned2023-12-06T14:10:15Z
dc.date.available2023-12-06T14:10:15Z
dc.date.issued2023-10-30
dc.identifier.issn0950-222Xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/186410
dc.description.abstractEnOBJECTIVE: To investigate clinical and spectral-domain optical coherence tomography (SD-OCT) biomarkers correlating with pre-injection visual acuity (VA), post-injection VA, and the likelihood of macular oedema (MO) regression following dexamethasone (DEX) implant injection in non-infectious uveitic (NIU) patients. METHODS: Patient data from Uveitis Services in Milan, Paris, and Berlin were analysed. Eligible participants were NIU patients aged >18 years with MO as the primary indication for DEX treatment. SD-OCT scans and clinical data were collected at the time of DEX injection (pre-injection visit) and after 3 months (post-injection visit). Multivariable regression models, adjusted for pre-injection VA and lens status, were employed to explore associations. MO regression was defined as the absence of intraretinal/subretinal fluid at the post-injection visit. RESULTS: Our analysis comprised data from 173 DEX treatments, encompassing 103 eyes from 80 patients, with 38 eyes (37%) receiving repeated DEX injections. The absence of the ellipsoid zone (EZ) layer and disorganisation of the inner retinal layers (DRIL) were associated with worse pre- (+0.19 LogMAR, 95% CI 0.01-0.38, p = 0.06, and +0.10 LogMAR, 95% CI 0.02-0.21, p = 0.01) and post-injection VA (+0.33 LogMAR, 95% CI 0.08-0.57, p = 0.01, and +0.17 LogMAR, 95% CI 0.01-0.32, p = 0.04). EZ disruption and DRIL increased significantly (p = 0.01 and p = 0.04), and the chance of gaining ≥5 letters declined in eyes undergoing repeated DEX (p = 0.002). The rate of MO regression after each DEX was 67%. Prolonged MO duration (OR = 0.75/each year, p = 0.02) was associated with reduced likelihood of MO regression. Subretinal fluid was associated with higher rate of MO regression (OR = 6.09, p = 0.01). CONCLUSION: Integrity of the inner and outer retina is associated with better visual response to DEX. Long-standing or recurrent MO is associated with less chance of both visual and anatomic response. Timely treatment is necessary to maximise the outcomes of MO in NIU patients.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enMacular oedema
dc.subject.enNon-infectious uveitis
dc.subject.enDexamethasone implant
dc.subject.enOptical coherence tomography
dc.title.enClinical and imaging biomarkers of response to intravitreal dexamethasone implant in eyes with non-infectious uveitic macular oedema
dc.title.alternativeEye (Lond)en_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41433-023-02802-7en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed37904001en_US
bordeaux.journalEyeen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamLEHA_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04328544
hal.version1
hal.date.transferred2023-12-07T09:29:13Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Eye&rft.date=2023-10-30&rft.eissn=0950-222X&rft.issn=0950-222X&rft.au=CICINELLI,%20Maria%20Vittoria&GEROSOLIMA,%20Claudia&SCANDALE,%20Pierluigi&TOUHAMI,%20Sarah&POHLMANN,%20Dominika&rft.genre=article


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