Hybrid Magnetic Nanoparticles for Targeted Delivery
Idioma
en
Chapitre d'ouvrage
Este ítem está publicado en
Comprehensive Biomaterials, Comprehensive Biomaterials. 2011 n° 4, p. 575-593
Elsevier
Resumen en inglés
Magnetic nanoparticles (MNPs) have attracted attention in modern medicine and pharmacology because of their potential usefulness as contrast agents for magnetic resonance imaging (MRI), as colloidal mediators for cancer ...Leer más >
Magnetic nanoparticles (MNPs) have attracted attention in modern medicine and pharmacology because of their potential usefulness as contrast agents for magnetic resonance imaging (MRI), as colloidal mediators for cancer magnetic hyperthermia or as active constituents of drug delivery platforms. This review examines these in vivo applications through an understanding of the involved problems and the current and future possibilities for resolving them. A special emphasis is made on MNP requirements from a physical viewpoint (e.g., relaxivity for MRI, specific absorption rate for hyperthermia, magnetic guidance), the factors affecting their biodistribution after intravenous injection (e.g., size, colloidal stability, surface hydrophobic/hydrophilic balance) and the solutions envisaged for enhancing their half-life in the blood compartment and targeting tumor cells.< Leer menos
Palabras clave en inglés
Biofunctionalization
Biomedical applications
Cancer
Contrast agent
Drug delivery
Hyperthermia
Magnetic fluids
Magnetic guidance
Magnetic nanoparticles
Magnetic resonance imaging
Stealthiness
Synthesis
Targeting
Orígen
Importado de HalCentros de investigación