Hybrid Magnetic Nanoparticles for Targeted Delivery
Language
en
Chapitre d'ouvrage
This item was published in
Comprehensive Biomaterials, Comprehensive Biomaterials. 2011 n° 4, p. 575-593
Elsevier
English Abstract
Magnetic nanoparticles (MNPs) have attracted attention in modern medicine and pharmacology because of their potential usefulness as contrast agents for magnetic resonance imaging (MRI), as colloidal mediators for cancer ...Read more >
Magnetic nanoparticles (MNPs) have attracted attention in modern medicine and pharmacology because of their potential usefulness as contrast agents for magnetic resonance imaging (MRI), as colloidal mediators for cancer magnetic hyperthermia or as active constituents of drug delivery platforms. This review examines these in vivo applications through an understanding of the involved problems and the current and future possibilities for resolving them. A special emphasis is made on MNP requirements from a physical viewpoint (e.g., relaxivity for MRI, specific absorption rate for hyperthermia, magnetic guidance), the factors affecting their biodistribution after intravenous injection (e.g., size, colloidal stability, surface hydrophobic/hydrophilic balance) and the solutions envisaged for enhancing their half-life in the blood compartment and targeting tumor cells.Read less <
English Keywords
Biofunctionalization
Biomedical applications
Cancer
Contrast agent
Drug delivery
Hyperthermia
Magnetic fluids
Magnetic guidance
Magnetic nanoparticles
Magnetic resonance imaging
Stealthiness
Synthesis
Targeting
Origin
Hal imported