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Effects of azithromycin and doxycycline on the vaginal microbiota of women with urogenital Chlamydia trachomatis infection: a substudy of the Chlazidoxy randomized controlled trial

hal.structure.identifierUniversité de Lausanne = University of Lausanne [UNIL]
dc.contributor.authorTAMARELLE, Jeanne
hal.structure.identifierBiodiversité, Gènes & Communautés [BioGeCo]
dc.contributor.authorPENAUD, Benjamin
hal.structure.identifierBiodiversité, Gènes & Communautés [BioGeCo]
dc.contributor.authorTYSSANDIER, Benjamin
hal.structure.identifierBiodiversité, Gènes & Communautés [BioGeCo]
dc.contributor.authorGUICHOUX, Erwan
hal.structure.identifierCHU Bordeaux
dc.contributor.authorDE BARBEYRAC, Bertille
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorPEUCHANT, Olivia
hal.structure.identifierCHU Bordeaux
dc.contributor.authorBAITA, Dounia
hal.structure.identifierCHU Bordeaux
dc.contributor.authorOUZIEL-DURETZ, Catherine
hal.structure.identifierCHU Bordeaux
dc.contributor.authorPOUDENS, Béatrice
hal.structure.identifierCHU Bordeaux
dc.contributor.authorBRUN, Raquel
hal.structure.identifierCHU Bordeaux
dc.contributor.authorJOUVERT, Sophie
hal.structure.identifierCHU Bordeaux
dc.contributor.authorTESSON, Aurore
hal.structure.identifierCHU Bordeaux
dc.contributor.authorCARRIÈRE, Jennifer
hal.structure.identifierCHU Bordeaux
dc.contributor.authorDIAZ, Marie
hal.structure.identifierCHU Bordeaux
dc.contributor.authorFORGET, Camille
dc.contributor.authorLE HEN, Isabelle
dc.contributor.authorAHANO-DUCOURNEAU, France
dc.contributor.authorVAN, Delphine Ha
dc.contributor.authorROBERT, Pauline
dc.contributor.authorBRUN, Fabienne
dc.contributor.authorLHOSPITAL, Estelle
dc.contributor.authorBARDOU, Julie
dc.contributor.authorGUEGAN, Annaïg
dc.contributor.authorMOURA, Sandy Ramloll
dc.contributor.authorLERICHE, Céline
dc.contributor.authorDE CUSSY, Alix
dc.contributor.authorMALFAIT, Marlène
dc.contributor.authorRYCHEN, Charlotte
dc.contributor.authorMARTINET, Pervenche
dc.contributor.authorKUGELER, Audrey
dc.contributor.authorBARRIERE, Lisa
dc.contributor.authorGUTIERREZ, Laura
dc.contributor.authorROBERT, Jean-Luc
dc.contributor.authorSAULE, Julie
dc.contributor.authorBERGAMASCHI, Viviana
dc.contributor.authorSOLTANA, Sana Ben
dc.contributor.authorAYMAR-MOULENE, Dominique
dc.contributor.authorBERNIER, Claire
dc.contributor.authorLECOMPTE, Anne-Sophie
dc.contributor.authorGREGOIRE, Antoine
dc.contributor.authorGIRARD, Thomas
dc.contributor.authorNACCACHE, Marie-Astrid
dc.contributor.authorLEFEBVRE, Philippe
dc.contributor.authorCROMBE, Pauline
dc.contributor.authorBULOT, Christine
dc.contributor.authorROLLAND, Anne-Laure
dc.contributor.authorDERNIVOIX, Katy
dc.contributor.authorTROUILLET, Camille
dc.contributor.authorTRIGNOL-VIGUIER, Nathalie
dc.contributor.authorBLIN-ZBIEGIEL, Elisabeth
dc.contributor.authorBOISSINOT, Mélanie
dc.contributor.authorJOLY, Bruno
dc.contributor.authorDUBREUIL, Anne
dc.contributor.authorMATHIEU, Camille
dc.contributor.authorPRAGOUT, David
dc.contributor.authorBÉBÉAR, Cécile
dc.contributor.authorGROB, Anne
dc.contributor.authorZAFFREYA, Sophie
dc.contributor.authorLE NAOUR, Erwan
dc.contributor.authorGIBAUD, Anne Sophie
dc.contributor.authorLANOTTE, Philippe
dc.contributor.authorVACHÉE, Anne
dc.contributor.authorLOUBINOUX, Julien
dc.contributor.authorTOUATI, Arabella
dc.contributor.authorBALCON, Carla
dc.contributor.authorROUSSILLON, Caroline
dc.contributor.authorGHEZZOUL, Bellabes
dc.contributor.authorPERRY, Frédéric
dc.contributor.authorTURUBAN, Christelle
dc.contributor.authorRAPIN, Sabine
dc.contributor.authorPASTOR, Christine
dc.contributor.authorCAVELLEC, Morane
dc.contributor.authorMANVRI, Ernesto Paredes
dc.contributor.authorALBANE, Sonia
dc.contributor.authorDERNIVOIX, Katy
dc.contributor.authorTROUILLET, Camille
dc.contributor.authorGHIRINGHELLI, Eva
dc.contributor.authorPANTIN, Karen
dc.contributor.authorKRET, Marion
dc.contributor.authorLHOMME, Edouard
dc.contributor.authorGARREAU, Damien
dc.contributor.authorGALET, Jérôme
dc.date.issued2023-08
dc.identifier.issn1198-743X
dc.description.abstractEnObjectives: Dysbiotic bacterial communities within the vagina are associated with Chlamydia trachomatis infection. We compared the effect of treatment with azithromycin and doxycycline on the vaginal microbiota in a cohort of women with a urogenital C. trachomatis infection randomly assigned to one of these treatments (Chlazidoxy trial). Methods: We analysed vaginal samples from 284 women (135 in the azithromycin group and 149 in the doxycycline group) collected at baseline and 6 weeks after treatment initiation. The vaginal microbiota was characterized using 16S rRNA gene sequencing and classified into community state types (CSTs). Results: At baseline, 75% (212/284) of the women had a high-risk microbiota (CST-III or CST-IV). A crosssectional comparison 6 weeks after treatment showed that 15 phylotypes were differentially abundant, but this difference was not reflected at the CST (p 0.772) or diversity level (p 0.339). Between baseline and the 6-week visit, a-diversity (p 0.140) and transition probabilities between CSTs were not significantly different between the groups, and no phylotype was differentially abundant. Discussion: In women with urogenital C. trachomatis infection, the vaginal microbiota does not seem to be affected by azithromycin or doxycycline 6 weeks after treatment. Because the vaginal microbiota remains susceptible to C. trachomatis infection (with CST-III or CST-IV) after antibiotic treatment, women remain at risk of reinfection, which could originate from unprotected sexual intercourse or untreated anorectal C. trachomatis infection. This last consideration advocates for the use of doxycycline instead of azithromycin because of its higher anorectal microbiological cure rate. Jeanne Tamarelle, Clin Microbiol Infect 2023;29:1056 & COPY; 2023 European Society of Clinical Microbiology and Infectious Diseases.
dc.description.sponsorshipPlateforme d'Innovation " Forêt-Bois-Fibre-Biomasse du Futur "
dc.language.isoen
dc.publisherElsevier for the European Society of Clinical Microbiology and Infectious Diseases
dc.subject.en16S rRNA gene sequencing
dc.subject.enAntibiotics
dc.subject.enChlamydia trachomatis treatment
dc.subject.enCommunity state types
dc.subject.enVaginal microbiome
dc.title.enEffects of azithromycin and doxycycline on the vaginal microbiota of women with urogenital Chlamydia trachomatis infection: a substudy of the Chlazidoxy randomized controlled trial
dc.typeArticle de revue
dc.identifier.doi10.1016/j.cmi.2023.04.020
dc.subject.halSciences de l'environnement
bordeaux.journalClinical Microbiology and Infection
bordeaux.page1056-1062
bordeaux.volume29
bordeaux.issue8
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-04183903
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-04183903v1
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