A Novel Tool to Identify Bactericidal Compounds against Vulnerable Targets in Drug-Tolerant M. tuberculosis found in Caseum
SHERMAN, David James
Pleiade, from patterns to models in computational biodiversity and biotechnology [PLEIADE]
< Réduire
Pleiade, from patterns to models in computational biodiversity and biotechnology [PLEIADE]
Langue
en
Article de revue
Ce document a été publié dans
mBio. 2023-04-25, vol. 14, n° 2
American Society for Microbiology
Résumé en anglais
M. tuberculosis (Mtb) within the caseous core of necrotic granulomas and cavities is extremely drug tolerant and presents a significant hurdle to treatment success and relapse prevention. Many in vitro models of nonreplicating ...Lire la suite >
M. tuberculosis (Mtb) within the caseous core of necrotic granulomas and cavities is extremely drug tolerant and presents a significant hurdle to treatment success and relapse prevention. Many in vitro models of nonreplicating persistence have been developed to characterize the physiologic and metabolic adaptations of Mtb and identify compounds active against this treatment-recalcitrant population.< Réduire
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Importé de halUnités de recherche