MENDES, Toni; RANFT, Jonas; BERTHOUMIEUX, Hélène

doi:10.1103/physreve.108.014113

Metadatos

Mostrar el registro completo del ítem

Licencia de uso del documento

MENDES, Toni
Laboratoire Ondes et Matière d'Aquitaine [LOMA]

RANFT, Jonas
Institut de biologie de l'ENS Paris [IBENS]

BERTHOUMIEUX, Hélène
Gulliver (UMR 7083)

Idioma

Article de revue

Este ítem está publicado en

Physical Review E. 2023-07-07, vol. 108

American Physical Society (APS)

Resumen en inglés

Many cellular organelles are membrane-bound structures with complex membrane composition and shape. Their shapes have been observed to depend on the metabolic state of the organelle and the mechanisms that couple biochemical pathways and membrane shape are still actively investigated. Here, we study a model coupling inhomogeneities in the lipid composition and membrane geometry via a generalized Helfrich free energy. We derive the resulting stress tensor, the Green's function for a tubular membrane, and compute the phase diagram of the induced deformations. We then apply this model to study the deformation of mitochondria cristae described as membrane tubes supporting a pH gradient at its surface. This gradient in turn controls the lipid composition of the membrane via the protonation or deprotonation of cardiolipins, which are acid-based lipids known to be crucial for mitochondria shape and functioning. Our model predicts the appearance of tube deformations resembling the observed shape changes of cristea when submitted to a proton gradient.< Leer menos

Metadatos

Licencia de uso del documento

Model of membrane deformations driven by a surface <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi>p</mml:mi><mml:mi mathvariant="normal">H</mml:mi></mml:mrow></mml:math> gradient

Idioma

Este ítem está publicado en

Resumen en inglés

DOI

Orígen

Centros de investigación