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Neurovascular hypoxia after mild traumatic brain injury in juvenile mice correlates with heart‐brain dysfunctions in adulthood

dc.rights.licenseopenen_US
dc.contributor.authorLEYBA, Katherine
dc.contributor.authorPAIYABHROMA, Nitchawat
dc.contributor.authorSALVAS, John
dc.contributor.authorDAMEN, Frederick
dc.contributor.authorJANVIER, Alicia
dc.contributor.authorZUB, Emma
dc.contributor.authorBERNIS, Corinne
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorROULAND, Richard
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorDUBOIS, Christophe
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorBADAUT, Jerome
hal.structure.identifierPhysiologie & médecine expérimentale du Cœur et des Muscles [U 1046] [PhyMedExp]
dc.contributor.authorRICHARD, Sylvain
dc.contributor.authorMARCHI, Nicola
dc.contributor.authorGOERGEN, Craig
hal.structure.identifierPhysiologie & médecine expérimentale du Cœur et des Muscles [U 1046] [PhyMedExp]
hal.structure.identifierCentre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
dc.contributor.authorSICARD, Pierre
dc.date.accessioned2023-11-16T15:21:26Z
dc.date.available2023-11-16T15:21:26Z
dc.date.issued2023-06-01
dc.identifier.issn1748-1708en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/184821
dc.description.abstractEnAim: Retrospective studies suggest that mild traumatic brain injury (mTBI) in pediatric patients may lead to an increased risk of cardiac events. However, the exact functional and temporal dynamics and the associations between heart and brain pathophysiological trajectories are not understood. Methods: A single impact to the left somatosensory cortical area of the intact skull was performed on juvenile mice (17 days postnatal). Cerebral 3D photoacoustic imaging was used to measure the oxygen saturation (sO2 ) in the impacted area 4 h after mTBI followed by 2D and 4D echocardiography at days 7, 30, 90, and 190 post-impact. At 8 months, we performed a dobutamine stress test to evaluate cardiac function. Lastly, behavioral analyses were conducted 1 year after initial injury. Results: We report a rapid and transient decrease in cerebrovascular sO2 and increased hemoglobin in the impacted left brain cortex. Cardiac analyses showed long-term diastolic dysfunction and a diminished systolic strain response under stress in the mTBI group. At the molecular level, cardiac T-p38MAPK and troponin I expression was pathologic modified post-mTBI. We found linear correlations between brain sO2 measured immediately post-mTBI and long-term cardiac strain after 8 months. We report that initial cerebrovascular hypoxia and chronic cardiac dysfunction correlated with long-term behavioral changes hinting at anxiety-like and memory maladaptation. Conclusion: Experimental juvenile mTBI induces time-dependent cardiac dysfunction that corresponds to the initial neurovascular sO2 dip and is associated with long-term behavioral modifications. These imaging biomarkers of the heart-brain axis could be applied to improve clinical pediatric mTBI management.
dc.description.sponsorshipFrance Life Imagingen_US
dc.description.sponsorshipNeurovascular damage determines disease pathophysiology in pediatric mild traumatic brain injury: source of new biomarkers - ANR-19-NEUR-0006en_US
dc.description.sponsorshipNouvelles modalités d'imagerie et de spectroscopie GABA pour localiser la zone épileptiqueen_US
dc.language.isoENen_US
dc.subject.en4D ultrasound
dc.subject.enDiastolic dysfunction
dc.subject.enHeart–brain axis
dc.subject.enPhotoacoustic imaging
dc.subject.enTraumatic brain injury
dc.title.enNeurovascular hypoxia after mild traumatic brain injury in juvenile mice correlates with heart‐brain dysfunctions in adulthood
dc.title.alternativeActa Physiol (Oxf)en_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1111/apha.13933en_US
dc.subject.halSciences du Vivant [q-bio]en_US
dc.subject.halSciences de l'ingénieur [physics]en_US
dc.identifier.pubmed36625322en_US
bordeaux.journalActa Physiologicaen_US
bordeaux.pagee13933en_US
bordeaux.volume238en_US
bordeaux.hal.laboratoriesCentre de Résonance Magnétique des Systèmes Biologiques (CRMSB) - UMR 5536en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation Leducqen_US
bordeaux.import.sourcehal
hal.identifierhal-03934124
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.cchttp://creativecommons.org/licenses/by-nc-nd/2.0/us/en_US
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