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A system for in vivo on-demand ultra-low field Overhauser-enhanced 3D-Magnetic resonance imaging.

dc.rights.licenseopenen_US
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorBOUDRIES, Dahmane
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorMASSOT, Philippe
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorPARZY, Elodie
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorSEREN, Seda
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorMELLET, Philippe
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorFRANCONI, Jean-Michel
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorMIRAUX, Sylvain
IDREF: 150967047
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorBEZANÇON, Eric
dc.contributor.authorMARQUE, Sylvain R A
dc.contributor.authorAUDRAN, Gérard
dc.contributor.authorMUETZEL, Markus
dc.contributor.authorWINTZHEIMER, Stefan
dc.contributor.authorFIDLER, Florian
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorTHIAUDIERE, Eric
dc.date.accessioned2023-11-15T16:52:42Z
dc.date.available2023-11-15T16:52:42Z
dc.date.issued2023-03-01
dc.identifier.issn1096-0856en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/184778
dc.description.abstractEnDevelopment of very-low field MRI is an active area of research. It aims at reducing operating costs and improve portability. However, the signal-to-noise issue becomes prominent at ultra-low field (<1 mT), especially for molecular imaging purposes that addresses specific biochemical events. In the context of preclinical molecular MRI of abnormal proteolysis the paper describes a MRI system able to produce Overhauser-enhanced MR images in living rats through in situ Dynamic Nuclear Polarization at 206 µT using stable and non-toxic nitroxides. In parallel conventional images are generated at 206 µT following pre-polarization at 20 mT. Results show that nitroxides are visualized in 3D within a few minutes in the lungs, kidneys and bladder post-administration. This system will be used for molecular imaging of inflammation using protease-specific nitroxide probes.
dc.language.isoENen_US
dc.subject.enRats
dc.subject.enAnimals
dc.subject.enMagnetic Resonance Spectroscopy
dc.subject.enMagnetic Resonance Imaging
dc.subject.enLung
dc.subject.enNitrogen Oxides
dc.title.enA system for in vivo on-demand ultra-low field Overhauser-enhanced 3D-Magnetic resonance imaging.
dc.title.alternativeJ Magn Resonen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.jmr.2023.107383en_US
dc.subject.halSciences du Vivant [q-bio]en_US
dc.subject.halSciences de l'ingénieur [physics]en_US
dc.identifier.pubmed36724576en_US
bordeaux.journalJournal of Magnetic Resonanceen_US
bordeaux.page107383en_US
bordeaux.volume348en_US
bordeaux.hal.laboratoriesCentre de Résonance Magnétique des Systèmes Biologiques (CRMSB) - UMR 5536en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04287932
hal.version1
hal.date.transferred2023-11-15T16:52:45Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Journal%20of%20Magnetic%20Resonance&amp;rft.date=2023-03-01&amp;rft.volume=348&amp;rft.spage=107383&amp;rft.epage=107383&amp;rft.eissn=1096-0856&amp;rft.issn=1096-0856&amp;rft.au=BOUDRIES,%20Dahmane&amp;MASSOT,%20Philippe&amp;PARZY,%20Elodie&amp;SEREN,%20Seda&amp;MELLET,%20Philippe&amp;rft.genre=article


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