1H-NMR metabolomics profiling of zebra mussel (Dreissena polymorpha): A field-scale monitoring tool in ecotoxicological studies
| dc.rights.license | open | en_US |
| hal.structure.identifier | Environnements et Paléoenvironnements OCéaniques [EPOC] | |
| dc.contributor.author | HANI, Younes
IDREF: 243033397 | |
| dc.contributor.author | PRUD'HOMME, Sophie Martine | |
| dc.contributor.author | NUZILLARD, Jean-Marc | |
| dc.contributor.author | BONNARD, Isabelle | |
| dc.contributor.author | ROBERT, Christelle
ORCID: 0000-0003-3497-6100 IDREF: 095820434 | |
| dc.contributor.author | NOTT, Katherine | |
| dc.contributor.author | RONKART, Sebastien | |
| dc.contributor.author | DEDOURGE-GEFFARD, Odile | |
| dc.contributor.author | GEFFARD, Alain | |
| dc.date.accessioned | 2023-11-15T09:47:53Z | |
| dc.date.available | 2023-11-15T09:47:53Z | |
| dc.date.issued | 2021-02-01 | |
| dc.identifier.issn | 0269-7491 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/184766 | |
| dc.description.abstractEn | Results of this study showed the interest of 1H-NMR metabolomics as an efficient approach in biomonitoring of aquatic environments, and lactate could be a potential biomarker. © 2020 Elsevier Ltd Biomonitoring of aquatic environments requires new tools to characterize the effects of pollutants on living organisms. Zebra mussels (Dreissena polymorpha) from the same site in north-eastern France were caged for two months, upstream and downstream of three wastewater treatment plants (WWTPs) in the international watershed of the Meuse (Charleville-Mézières “CM” in France, Namur “Nam” and Charleroi “Cr” in Belgium). The aim was to test 1H-NMR metabolomics for the assessment of water bodies’ quality. The metabolomic approach was combined with a more “classical” one, i.e., the measurement of a range of energy biomarkers: lactate dehydrogenase (LDH), lipase, acid phosphatase (ACP) and amylase activities, condition index (CI), total reserves, electron transport system (ETS) activity and cellular energy allocation (CEA). Five of the eight energy biomarkers were significantly impacted (LDH, ACP, lipase, total reserves and ETS), without a clear pattern between sites (Up and Down) and stations (CM, Nam and Cr). The metabolomic approach revealed variations among the three stations, and also between the upstream and downstream of Nam and CM WWTPs. A total of 28 known metabolites was detected, among which four (lactate, glycine, maltose and glutamate) explained the observed metabolome variations between sites and stations, in accordance with chemical exposure levels. Metabolome changes suggest that zebra mussel exposure to field contamination could alter their osmoregulation and anaerobic metabolism capacities. This study reveals that lactate is a potential biomarker of interest, and 1H-NMR metabolomics can be an efficient approach to assess the health status of zebra mussels in the biomonitoring of aquatic environments. © 2020 Elsevier Ltd | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
| dc.subject.en | Acid Phosphatase | |
| dc.subject.en | Active Biomonitoring | |
| dc.subject.en | Amino Acids | |
| dc.subject.en | Anaerobic Metabolism | |
| dc.subject.en | Anaerobic Metabolism | |
| dc.subject.en | Analysis | |
| dc.subject.en | Animal | |
| dc.subject.en | Animals | |
| dc.subject.en | Aquatic Environment | |
| dc.subject.en | Aquatic Environments | |
| dc.subject.en | Belgium | |
| dc.subject.en | Biological Marker | |
| dc.subject.en | Biological Monitoring | |
| dc.subject.en | Biomarker | |
| dc.subject.en | Biomarkers | |
| dc.subject.en | Bivalve | |
| dc.subject.en | Cell Energy | |
| dc.subject.en | Chemical | |
| dc.subject.en | Chemical Exposure | |
| dc.subject.en | Condition Index | |
| dc.subject.en | Contamination | |
| dc.subject.en | Controlled Study | |
| dc.subject.en | Dreissena | |
| dc.subject.en | Dreissena Polymorpha | |
| dc.subject.en | Ecotoxicological Study | |
| dc.subject.en | Ecotoxicology | |
| dc.subject.en | Electron Transport | |
| dc.subject.en | Electron Transport Properties | |
| dc.subject.en | Electron Transport Systems | |
| dc.subject.en | Energy | |
| dc.subject.en | Energy Metabolism | |
| dc.subject.en | Environmental Assessment | |
| dc.subject.en | Environmental Fate | |
| dc.subject.en | Environmental Monitoring | |
| dc.subject.en | Environmental Monitoring | |
| dc.subject.en | Enzyme Activity | |
| dc.subject.en | Field Contamination | |
| dc.subject.en | France | |
| dc.subject.en | Glutamic Acid | |
| dc.subject.en | Glycine | |
| dc.subject.en | Health Status | |
| dc.subject.en | Lactate Dehydrogenase | |
| dc.subject.en | Lactate Dehydrogenase | |
| dc.subject.en | Lactic Acid | |
| dc.subject.en | Living Organisms | |
| dc.subject.en | Maltose | |
| dc.subject.en | Metabolites | |
| dc.subject.en | Metabolomics | |
| dc.subject.en | Metabolomics | |
| dc.subject.en | Mollusc | |
| dc.subject.en | Molluscs | |
| dc.subject.en | Monitoring | |
| dc.subject.en | Nonhuman | |
| dc.subject.en | Osmoregulation | |
| dc.subject.en | Parameters | |
| dc.subject.en | Phosphatases | |
| dc.subject.en | Physiological Response | |
| dc.subject.en | Proton Magnetic Resonance Spectroscopy | |
| dc.subject.en | Proton Nuclear Magnetic Resonance | |
| dc.subject.en | Rivers | |
| dc.subject.en | Sewage Treatment Plants | |
| dc.subject.en | Total Reserve | |
| dc.subject.en | Toxicity | |
| dc.subject.en | Triacylglycerol Lipase | |
| dc.subject.en | Waste Water Treatment Plant | |
| dc.subject.en | Wastewater Treatment | |
| dc.subject.en | Wastewater Treatment Plants | |
| dc.subject.en | Water Pollutant | |
| dc.subject.en | Water Pollutants | |
| dc.subject.en | Water Quality | |
| dc.subject.en | Watershed | |
| dc.title.en | 1H-NMR metabolomics profiling of zebra mussel (Dreissena polymorpha): A field-scale monitoring tool in ecotoxicological studies | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.envpol.2020.116048 | en_US |
| dc.subject.hal | Sciences de l'environnement | en_US |
| bordeaux.journal | Environmental Pollution | en_US |
| bordeaux.volume | 270 | en_US |
| bordeaux.hal.laboratories | EPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.team | EA | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| dc.rights.cc | CC BY-NC-ND | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Environmental%20Pollution&rft.date=2021-02-01&rft.volume=270&rft.eissn=0269-7491&rft.issn=0269-7491&rft.au=HANI,%20Younes&PRUD'HOMME,%20Sophie%20Martine&NUZILLARD,%20Jean-Marc&BONNARD,%20Isabelle&ROBERT,%20Christelle&rft.genre=article |
