The Mortality of Infective endocarditis with and without Surgery in the Elderly (MoISE) study
| dc.rights.license | open | en_US |
| dc.contributor.author | HÉMAR, Victor | |
| dc.contributor.author | CAMOU, Fabrice | |
| hal.structure.identifier | BoRdeaux Institute in onCology [Inserm U1312 - BRIC] | |
| dc.contributor.author | ROUBAUD, Claire | |
| dc.contributor.author | TERNACLE, Julien | |
| dc.contributor.author | PERNOT, Mathieu | |
| dc.contributor.author | GREIB, Carine | |
| dc.contributor.author | DIJOS, Marina | |
| dc.contributor.author | WIRTH, Gaetane | |
| dc.contributor.author | CHAUSSADE, Hélène | |
| dc.contributor.author | PEUCHANT, Olivia | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| hal.structure.identifier | Global Health in the Global South [GHiGS] | |
| dc.contributor.author | BONNET, Fabrice | |
| dc.contributor.author | ISSA, N | |
| dc.date.accessioned | 2023-11-07T14:45:56Z | |
| dc.date.available | 2023-11-07T14:45:56Z | |
| dc.date.issued | 2023-06-27 | |
| dc.identifier.issn | 1537-6591 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/184671 | |
| dc.description.abstractEn | Infective endocarditis (IE) is increasingly affecting older patients, but data on their management are sparse and the benefits of surgery in this population are unclear. We included patients with left-sided IE (LSIE) aged ≥ 80 years enrolled in a prospective endocarditis cohort managed in Aquitaine, France from 2013 to 2020. Geriatric data were collected retrospectively to identify factors associated with the 1-year risk of death using Cox regression. We included 163 patients with LSIE (median age, 84 years; men, 59%; rate of prosthetic LSIE, 45%). Of the 105 (64%) patients with potential surgical indications, 38 (36%) underwent valve surgery: they were younger, more likely to be men with aortic involvement, and had a lower Charlson Comorbidity Index. Moreover, they had better functional status at admission (i.e., the ability to walk unassisted and a higher median Activities of Daily Living [ADL] score [n = 5/6 vs. 3/6, p = 0.01]).The 1-year mortality rate in LSIE patients without surgical indications was 28%; it was lower in those who were operated on compared to those who were not despite a surgical indication (16% vs. 66%, p < 0.001). Impaired functional status at admission was strongly associated with mortality regardless of surgical status. In patients unable to walk unassisted or with an ADL score < 4, there was no significant surgical benefit for 1-year mortality. Surgery improves the prognosis of older patients with LSIE and good functional status. Surgical futility should be discussed in patients with altered autonomy. The endocarditis team should include a geriatric specialist. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Cardiac surgery | |
| dc.subject.en | Functional status | |
| dc.subject.en | Infective endocarditis | |
| dc.subject.en | Older patients | |
| dc.subject.en | Prognosis | |
| dc.title.en | The Mortality of Infective endocarditis with and without Surgery in the Elderly (MoISE) study | |
| dc.title.alternative | Clin Infect Dis | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1093/cid/ciad384 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 37369092 | en_US |
| bordeaux.journal | Clinical Infectious Diseases | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | GHIGS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | ViiV Healthcare | en_US |
| bordeaux.identifier.funderID | Gilead Sciences | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-04273913 | |
| hal.version | 1 | |
| hal.date.transferred | 2023-11-07T14:45:58Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Clinical%20Infectious%20Diseases&rft.date=2023-06-27&rft.eissn=1537-6591&rft.issn=1537-6591&rft.au=H%C3%89MAR,%20Victor&CAMOU,%20Fabrice&ROUBAUD,%20Claire&TERNACLE,%20Julien&PERNOT,%20Mathieu&rft.genre=article |
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