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dc.rights.licenseopenen_US
dc.contributor.authorBLENGIO, Fabiola
dc.contributor.authorHOCINI, Hakim
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRICHERT, Laura
dc.contributor.authorLEFEBVRE, Cécile
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDURAND, Melany
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHEJBLUM, Boris
ORCID: 0000-0003-0646-452X
IDREF: 189970316
dc.contributor.authorTISSERAND, Pascaline
dc.contributor.authorMCLEAN, Chelsea
dc.contributor.authorLUHN, Kerstin
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTHIEBAUT, Rodolphe
dc.contributor.authorLEVY, Yves
dc.date.accessioned2023-11-07T14:41:55Z
dc.date.available2023-11-07T14:41:55Z
dc.date.issued2023-09-26
dc.identifier.issn2211-1247en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/184670
dc.description.abstractEnEbola virus disease is a severe hemorrhagic fever with a high fatality rate. We investigate transcriptome profiles at 3 h, 1 day, and 7 days after vaccination with Ad26.ZEBOV and MVA-BN-Filo. 3 h after Ad26.ZEBOV injection, we observe an increase in genes related to antigen presentation, sensing, and T and B cell receptors. The highest response occurs 1 day after Ad26.ZEBOV injection, with an increase of the gene expression of interferon-induced antiviral molecules, monocyte activation, and sensing receptors. This response is regulated by the HESX1, ATF3, ANKRD22, and ETV7 transcription factors. A plasma cell signature is observed on day 7 post-Ad26.ZEBOV vaccination, with an increase of CD138, MZB1, CD38, CD79A, and immunoglobulin genes. We have identified early expressed genes correlated with the magnitude of the antibody response 21 days after the MVA-BN-Filo and 364 days after Ad26.ZEBOV vaccinations. Our results provide early gene signatures that correlate with vaccine-induced Ebola virus glycoprotein-specific antibodies.
dc.description.sponsorshipInitiative for the creation of a Vaccine Research Institute - ANR-10-LABX-0077en_US
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enHumans
dc.subject.enEbola Vaccines
dc.subject.enHemorrhagic Fever
dc.subject.enEbola
dc.subject.enAntibody Formation
dc.subject.enEbolavirus
dc.subject.enTranscriptome
dc.subject.enVaccination
dc.subject.enAntibodies
dc.subject.enViral
dc.subject.enVaccinia virus
dc.title.enIdentification of early gene expression profiles associated with long-lasting antibody responses to the Ebola vaccine Ad26.ZEBOV/MVA-BN-Filo
dc.title.alternativeCell Repen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.celrep.2023.113101en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed37691146en_US
dc.description.sponsorshipEuropeHorizon 2020 research and innovation programmeen_US
bordeaux.journalCell Reportsen_US
bordeaux.page113101en_US
bordeaux.volume42en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue9en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionINRIAen_US
bordeaux.teamSISTMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInnovative Medicines Initiativeen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04273901
hal.version1
hal.date.transferred2023-11-07T14:41:58Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cell%20Reports&rft.date=2023-09-26&rft.volume=42&rft.issue=9&rft.spage=113101&rft.epage=113101&rft.eissn=2211-1247&rft.issn=2211-1247&rft.au=BLENGIO,%20Fabiola&HOCINI,%20Hakim&RICHERT,%20Laura&LEFEBVRE,%20C%C3%A9cile&DURAND,%20Melany&rft.genre=article


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