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dc.rights.licenseopenen_US
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorPIERRON, Fabien
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorGONZALEZ, Patrice
ORCID: 0000-0003-2628-2993
IDREF: 14341917X
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorBERTUCCI, Anthony
dc.contributor.authorBINIAS, Cindy
dc.contributor.authorMEROUR, Emilie
dc.contributor.authorBREMONT, Michel M
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorDE MONTAUDOUIN, Xavier
IDREF: 075931664
dc.date.accessioned2023-10-02T08:44:46Z
dc.date.available2023-10-02T08:44:46Z
dc.date.issued2019-03-01
dc.identifier.issn1050-4648en_US
dc.identifier.urioai:crossref.org:10.1016/j.fsi.2018.11.043
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/183845
dc.description.abstractEnRecently, we reported an emerging pathology named Brown Muscle Disease (BMD) affecting Asari clams inhabiting the most productive area for this species in France, the Arcachon Bay. The main macroscopic feature of the pathology relies on the atrophy of the posterior adductor muscle, affecting the ability of clams to burry. The research of the etiological agent of BMD privileged a viral infection. Contrary to healthy clams, infected animals are always found at the surface of the sediment and exhibit 30 nm virus-like particles in muscle, granulocytic and rectal cells. In order to get more insights on the etiology and impacts of the BMD on clams, we took advantage in the present study of next generation sequencing technologies. An RNA-Seq approach was used (i) to test whether viral RNA sequences can be specifically found in the transcriptome of diseased animals and (ii) to identify the genes that are differentially regulated between diseased and healthy clams. Contrary to healthy buried animals, in diseased clams one sequence showing extensive homologies with retroviridae-related genes was detected. Among the biological processes that were affected in diseased clams, the synaptic transmission process was the most represented. To deepen this result, a new sampling was carried out and the transcription level of genes involved in synaptic transmission was determined in healthy and diseased clams but also in clams with no visible sign of pathology but located at the surface of the sediment. Our findings suggest that muscle atrophy is a latter sign of the pathology and that nervous system could be instead a primary target of the BMD agent.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.sourcecrossref
dc.title.enTranscriptome-wide analysis of wild Asari (=Manila) clams affected by the Brown Muscle Disease: Etiology and impacts of the disease
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.fsi.2018.11.043en_US
dc.subject.halSciences de l'environnementen_US
bordeaux.journalFish and Shellfish Immunologyen_US
bordeaux.page179-185en_US
bordeaux.volume86en_US
bordeaux.hal.laboratoriesEPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.teamECOBIOCen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcedissemin
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcedissemin
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Fish%20and%20Shellfish%20Immunology&rft.date=2019-03-01&rft.volume=86&rft.spage=179-185&rft.epage=179-185&rft.eissn=1050-4648&rft.issn=1050-4648&rft.au=PIERRON,%20Fabien&GONZALEZ,%20Patrice&BERTUCCI,%20Anthony&BINIAS,%20Cindy&MEROUR,%20Emilie&rft.genre=article


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