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Epigenetic modifications linked to memory impairments induced by a high-fat diet during adolescence

dc.rights.licenseopenen_US
dc.contributor.authorBORA, Ambica
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorHELBLING, Jean-Christophe
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBAKOGIANNIS, Ioannis
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDUCOURNEAU, Eva
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorFERREIRA, Guillaume
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMOISAN, Marie-Pierre
dc.date.accessioned2023-09-13T12:06:31Z
dc.date.available2023-09-13T12:06:31Z
dc.date.conference2021-05-19
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/183666
dc.description.abstractEnWe have previously reported that an unrestricted high fat diet consumed during the adolescence period has been causally linked with hippocampal memory impairments in adulthood. Causal mechanisms reported include, prolonged stress induced inflammatory response, neuronal hyperexcitability and cerebral plasticity disruption in hippocampus. In this study we have looked at hippocampal gene expression and protein levels in mice fed normal chow (NC) or high fat (HF) diet for 12 weeks since weaning and sacrificed 30 min after the training phase of contextual fear conditioning (CFC), a classical hippocampus-dependent memory test, and compared them to home cage controls. We found that many immediate early genes were induced by CFC in both NC and HF groups compared to controls. Interestingly, 2-way ANOVA diet by CFC interaction was found for genes encoding for epigenetic modifiers such as histone deacetylase (Hdac3) and DNA methylase (Dnmt3a) or histone methylase (Suv39h2). Finally, phosphorylated glucocorticoid receptor was upregulated and BDNF downregulated in CFC mice on HF diet. These data are interesting in view of similar modifications observed in hippocampus in age-related memory impairments.
dc.language.isoENen_US
dc.title.enEpigenetic modifications linked to memory impairments induced by a high-fat diet during adolescence
dc.typePosteren_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
bordeaux.hal.laboratoriesNutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.institutionBordeaux INP
bordeaux.conference.titleNeuroFrance 2021en_US
bordeaux.countryfren_US
hal.invitedouien_US
hal.conference.end2021-05-21
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.au=BORA,%20Ambica&HELBLING,%20Jean-Christophe&BAKOGIANNIS,%20Ioannis&DUCOURNEAU,%20Eva&FERREIRA,%20Guillaume&rft.genre=unknown


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