FRANCIS-OLIVIERO, Florence; ENAUD, Raphael; SORET, Perrine; LUSSAC-SORTON, Florian; AVALOS FERNANDEZ, Marta; MUCOFONG INVESTIGATION, Group; BUI, Stephanie; FAYON, Michael; THIEBAUT, Rodolphe; DELHAES, Laurence

doi:10.3390/jcm10163725

Bordeaux population health [BPH]

ENAUD, Raphael

Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]

SORET, Perrine
Statistics In System biology and Translational Medicine [SISTM]
Bordeaux population health [BPH]

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Ce document a été publié dans

Journal of Clinical Medicine. 2021-08-21, vol. 10, n° 16

Résumé en anglais

Several predictive models have been proposed to understand the microbial risk factors associated with cystic fibrosis (CF) progression. Very few have integrated fungal airways colonisation, which is increasingly recognized as a key player regarding CF progression. To assess the association between the percent predicted forced expiratory volume in 1 s (ppFEV1) change and the fungi or bacteria identified in the sputum, 299 CF patients from the "MucoFong" project were included and followed-up with over two years. The relationship between the microorganisms identified in the sputum and ppFEV1 course of patients was longitudinally analysed. An adjusted linear mixed model analysis was performed to evaluate the effect of a transient or chronic bacterial and/or fungal colonisation at inclusion on the ppFEV1 change over a two-year period. Pseudomonas aeruginosa, Achromobacter xylosoxidans, Stenotrophomonas maltophilia, and Candida albicans were associated with a significant ppFEV1 decrease. No significant association was found with other fungal colonisations. In addition, the ppFEV1 outcome in our model was 11.26% lower in patients presenting with a transient colonisation with non-pneumoniae Streptococcus species compared to other patients. These results confirm recently published data and provide new insights into bacterial and fungal colonisation as key factors for the assessment of lung function decline in CF patients.< Réduire

Mots clés en anglais

Cystic fibrosis

Longitudinal analysis

Aspergillus fumigatus

Candida albicans

Mycobiota

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https://oskar-bordeaux.fr/handle/20.500.12278/182830

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http://dx.doi.org/10.3390/jcm10163725

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New Insights in Microbial Species Predicting Lung Function Decline in CF: Lessons from the MucoFong Project

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New Insights in Microbial Species Predicting Lung Function Decline in CF: Lessons from the MucoFong Project

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