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dc.rights.licenseopenen_US
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorMARTIN, Anouk
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLALANNE, Pierre
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorVAX, Amélie
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorMUTSCHLER, Angela
IDREF: 224745379
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
dc.date.accessioned2023-06-21T16:25:31Z
dc.date.available2023-06-21T16:25:31Z
dc.date.issued2023-06-20
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182756
dc.description.abstractEnThe self-assembly of poly(ethylene glycol)-block-poly(trimethylene carbonate) PEG-b-PTMC copolymers into vesicles, also referred as polymersomes, was evaluated by solvent displacement using microfluidic systems. Two microfluidic chips with different flow regimes (micromixer and Herringbone) were used and the impact of process conditions on vesicle formation was evaluated. As polymersomes are sensitive to osmotic variations, their preparation under conditions allowing their direct use in biological medium is of major importance. We therefore developed a solvent exchange approach from DMSO (Dimethylsulfoxide) to aqueous media with an osmolarity of 300 mOsm.L-1, allowing their direct use for biological evaluation. We evidenced that the organic/aqueous solvent ratio does not impact vesicle size, but the total flow rate and copolymer concentration have been observed to influence the size of polymersomes. Finally, nanoparticles with diameters ranging from 76 nm to 224 nm were confirmed to be vesicles through the use of multi-angle light scattering in combination with cryo-TEM (Cryo-Transmission Electron Microscopy) characterization.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subject.enMicrofluidic
dc.subject.enpolymersomes
dc.subject.ensize control
dc.subject.enself-assembly
dc.subject.ennanomedicine
dc.title.enControlling Polymersome Size through Microfluidic-Assisted Self-Assembly: Enabling 'Ready to Use' formulations for biological applications
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.ijpharm.2023.123157en_US
dc.subject.halChimie/Polymèresen_US
bordeaux.journalInternational Journal of Pharmaceuticsen_US
bordeaux.page123157en_US
bordeaux.volume642en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04136854
hal.version1
hal.date.transferred2023-06-21T16:25:34Z
hal.exporttrue
dc.rights.ccCC BY-NC-SAen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=International%20Journal%20of%20Pharmaceutics&rft.date=2023-06-20&rft.volume=642&rft.spage=123157&rft.epage=123157&rft.au=MARTIN,%20Anouk&LALANNE,%20Pierre&VAX,%20Am%C3%A9lie&MUTSCHLER,%20Angela&LECOMMANDOUX,%20Sebastien&rft.genre=article


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