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Circulating Human Serum Metabolites Derived from the Intake of a Saffron Extract (Safr'Inside) Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders.

dc.rights.licenseopenen_US
hal.structure.identifierClinic'n'Cell SAS
dc.contributor.authorWAUQUIER, Fabien
hal.structure.identifierClinic'n'Cell SAS
dc.contributor.authorBOUTIN-WITTRANT, Line
hal.structure.identifierActiv'Inside
dc.contributor.authorPOURTAU, Line
hal.structure.identifierActiv'Inside
dc.contributor.authorGAUDOUT, David
hal.structure.identifierActiv'Inside
dc.contributor.authorMORAS, Benjamin
hal.structure.identifierActiv'Inside
dc.contributor.authorVIGNAULT, Adeline
hal.structure.identifierActiv'Inside
dc.contributor.authorMONCHAUX DE OLIVEIRA, Camille
hal.structure.identifierActiv'Inside
dc.contributor.authorGABASTON, Julien
hal.structure.identifierEquipe Nutrition, Santé et Biochimie des Lipides [ITERG]
dc.contributor.authorVAYSSE, Carole
hal.structure.identifierEquipe Nutrition, Santé et Biochimie des Lipides [ITERG]
dc.contributor.authorBERTRAND, Karene
hal.structure.identifierEquipe Nutrition, Santé et Biochimie des Lipides [ITERG]
dc.contributor.authorABROUS, Helene
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorCAPURON, Lucile
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorCASTANON, Nathalie
ORCID: 0000-0002-0079-0562
IDREF: 131871943
dc.contributor.authorVAUZOUR, David
dc.contributor.authorROUX, Véronique
dc.contributor.authorMACIAN, Nicolas
dc.contributor.authorPICKERING, Gisèle
hal.structure.identifierUnité de Nutrition Humaine [UNH]
dc.contributor.authorWITTRANT, Yohann
dc.date.accessioned2023-06-14T12:47:48Z
dc.date.available2023-06-14T12:47:48Z
dc.date.issued2022-04-05
dc.identifier.issn2072-6643en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182688
dc.description.abstractEnIncreases in oxidative stress have been reported to play a central role in the vulnerability to depression, and antidepressant drugs may reduce increased oxidative stress in patients. Among the plants exerting anti-inflammatory and anti-oxidant properties, saffron, a spice derived from the flower of , is also known for its positive effects on depression, potentially through its SSRI-like properties. However, the molecular mechanisms underlying these effects and their health benefits for humans are currently unclear. Using an original ex vivo clinical approach, we demonstrated for the first time that the circulating human metabolites produced following saffron intake (Safr'Inside) protect human neurons from oxidative-stress-induced neurotoxicity by preserving cell viability and increasing BNDF production. In particular, the metabolites significantly stimulated both dopamine and serotonin release. In addition, the saffron's metabolites were also able to protect serotonergic tone by inhibiting the expression of the serotonin transporter SERT and down-regulating serotonin metabolism. Altogether, these data provide new biochemical insights into the mechanisms underlying the beneficial impact of saffron on neuronal viability and activity in humans, in the context of oxidative stress related to depression.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectClinical trial
dc.subjectDepression
dc.subjectBDNF
dc.subjectDopamine
dc.subjectSERT
dc.subjectBrain
dc.subjectMental health
dc.subjectCrocetin
dc.subjectSH-SY5Y
dc.subject.enCrocus
dc.subject.enDepressive Disorder
dc.subject.enHumans
dc.subject.enNeurons
dc.subject.enOxidative Stress
dc.subject.enPlant Extracts
dc.subject.enSerotonin
dc.title.enCirculating Human Serum Metabolites Derived from the Intake of a Saffron Extract (Safr'Inside) Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders.
dc.title.alternativeNutrientsen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/nu14071511en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed35406124en_US
bordeaux.journalNutrientsen_US
bordeaux.volume14en_US
bordeaux.hal.laboratoriesNutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue7en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
bordeaux.import.sourcepubmed
hal.exportfalse
workflow.import.sourcepubmed
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nutrients&rft.date=2022-04-05&rft.volume=14&rft.issue=7&rft.eissn=2072-6643&rft.issn=2072-6643&rft.au=WAUQUIER,%20Fabien&BOUTIN-WITTRANT,%20Line&POURTAU,%20Line&GAUDOUT,%20David&MORAS,%20Benjamin&rft.genre=article


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