LE, Duc H T; IBRAHIMOVA, Vusala; VAN DEN WILDENBERG, Sebastian A H; WU, Hanglong; FONSECA, Alba; TORRES, Tomas; GARANGER, Elisabeth; LEENDERS, William P J; BROCK, Roland; LECOMMANDOUX, Sébastien; VAN HEST, Jan C M

doi:10.1002/anie.202300511

LE, Duc H T
Department of Biomedical Engineering [Eindhoven]
Radboud Institute for Molecular Life Sciences [Nijmegen, the Netherlands]

IBRAHIMOVA, Vusala
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

VAN DEN WILDENBERG, Sebastian A H
Department of Biomedical Engineering [Eindhoven]

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Ce document a été publié dans

Angewandte Chemie International Edition. 2023-04-21, vol. 62, p. e202300511

Résumé en anglais

We describe here a near infrared light-responsive elastin-like peptide (ELP)-based targeted nanoparticle (NP) that can rapidly switch its size from 120 to 25 nm upon photo-irradiation. Interestingly, the targeting function, which is crucial for effective cargo delivery, is preserved after transformation. The NPs are assembled from (targeted) diblock ELP micelles encapsulating photosensitizer TT1-monoblock ELP conjugates. Methionine residues in this monoblock are photo-oxidized by singlet oxygen generated from TT1, turning the ELPs hydrophilic and thus trigger NP dissociation. Phenylalanine residues from the diblocks then interact with TT1 via π-π stacking, inducing the re-formation of smaller NPs. Due to their small size and targeting function, the NPs penetrate deeper in spheroids and kill cancer cells more efficiently compared to the larger ones. This work could contribute to the design of "smart" nanomedicines with deeper penetration capacity for effective anticancer therapies.< Réduire

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https://oskar-bordeaux.fr/handle/20.500.12278/182351

DOI

http://dx.doi.org/10.1002/anie.202300511

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Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629

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Light-Responsive Elastin-Like Peptide-Based Targeted Nanoparticles for Enhanced Spheroid Penetration.

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