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The puzzle of quality of life in schizophrenia: putting the pieces together with the FACE-SZ cohort

dc.rights.licenseopenen_US
dc.contributor.authorEHRMINGER, Mickael
dc.contributor.authorROUX, Paul
dc.contributor.authorURBACH, Mathieu
dc.contributor.authorANDRE, Myrtille
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAOUIZERATE, Bruno
dc.contributor.authorBERNA, Fabrice
dc.contributor.authorBOHEC, Anne-Lise
dc.contributor.authorCAPDEVIELLE, Delphine
dc.contributor.authorCHEREAU, Isabelle
dc.contributor.authorCLAUSS, Julie
dc.contributor.authorDUBERTRET, Caroline
dc.contributor.authorDUBREUCQ, Julien
dc.contributor.authorFOND, Guillaume
dc.contributor.authorHONCIUC, Roxana-Mihaela
dc.contributor.authorLANCON, Christophe
dc.contributor.authorLAOUAMRI, Hakim
dc.contributor.authorLEIGNER, Sylvain
dc.contributor.authorMALLET, Jasmina
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorMISDRAHI, David
dc.contributor.authorPIGNON, Baptiste
dc.contributor.authorREY, Romain
dc.contributor.authorSCHURHOFF, Franck
dc.contributor.authorPASSERIEUX, Christine
dc.contributor.authorBRUNET-GOUET, Eric
dc.date.accessioned2023-05-24T09:32:12Z
dc.date.available2023-05-24T09:32:12Z
dc.date.issued2020-09-23
dc.identifier.issn0033-2917en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182289
dc.description.abstractEnBackground The determinants of quality of life (QoL) in schizophrenia are largely debated, mainly due to methodological discrepancies and divergence about the concepts concerned. As most studies have investigated bi- or tri-variate models, a multivariate model accounting for simultaneous potential mediations is necessary to have a comprehensive view of the determinants of QOL. We sought to estimate the associations between cognitive reserve, cognition, functioning, insight, depression, schizophrenic symptoms, and QoL in schizophrenia and their potential mediation relationships. Methods We used structural equation modeling with mediation analyses to test a model based on existing literature in a sample of 776 patients with schizophrenia from the FondaMental Foundation FACE-SZ cohort. Results Our model showed a good fit to the data. We found better functioning to be positively associated with a better QoL, whereas better cognition, better insight, higher levels of depression, and schizophrenic symptoms were associated with a lower QoL in our sample. Cognitive reserve is not directly linked to QoL, but indirectly in a negative manner via cognition. We confirm the negative relationship between cognition and subjective QoL which was previously evidenced by other studies; moreover, this relationship seems to be robust as it survived in our multivariate model. It was not explained by insight as some suggested, thus the mechanism at stake remains to be explained. Conclusion The pathways to subjective QoL in schizophrenia are complex and the determinants largely influence each other. Longitudinal studies are warranted to confirm these cross-sectional findings.
dc.description.sponsorshipSorbonne Universités à Paris pour l'Enseignement et la Rechercheen_US
dc.description.sponsorshipFondaMental-Cohortes - ANR-10-COHO-0010en_US
dc.language.isoENen_US
dc.subject.enCognition
dc.subject.enmediation analyses
dc.subject.enquality of life
dc.subject.enstructural equation modeling
dc.title.enThe puzzle of quality of life in schizophrenia: putting the pieces together with the FACE-SZ cohort
dc.typeArticle de revueen_US
dc.identifier.doi10.1017/S0033291720003311en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Psychiatrie et santé mentaleen_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]/Psychologie et comportementsen_US
dc.identifier.pubmed32962773en_US
bordeaux.journalPsychological Medicineen_US
bordeaux.page1-8en_US
bordeaux.volume52en_US
bordeaux.hal.laboratoriesNutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue8en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.institutionCNRS
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-03338446
hal.version1
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Psychological%20Medicine&rft.date=2020-09-23&rft.volume=52&rft.issue=8&rft.spage=1-8&rft.epage=1-8&rft.eissn=0033-2917&rft.issn=0033-2917&rft.au=EHRMINGER,%20Mickael&ROUX,%20Paul&URBACH,%20Mathieu&ANDRE,%20Myrtille&AOUIZERATE,%20Bruno&rft.genre=article


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