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Inhibition of striatonigral autophagy as a link between cannabinoid intoxication and impairment of motor coordination

dc.rights.licenseopenen_US
dc.contributor.authorBLAZQUEZ, Cristina
dc.contributor.authorRUIZ-CALVO, Andrea
dc.contributor.authorBAJO-GRANERAS, Raquel
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorBAUFRETON, Jerome M.
dc.contributor.authorRESEL, Eva
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorVARILH, Marjorie
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorPAGANO ZOTTOLA, Antonio C.
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMARIANI, Yamuna
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorCANNICH, Astrid
dc.contributor.authorRODRIGUEZ-NAVARRO, Jose A.
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMARSICANO, Giovanni
dc.contributor.authorGALVE-ROPERH, Ismael
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorBELLOCCHIO, Luigi
dc.contributor.authorGUZMAN, Manuel
dc.date.accessioned2023-05-24T09:04:03Z
dc.date.available2023-05-24T09:04:03Z
dc.date.issued2020-08-10
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182286
dc.description.abstractEnThe use of cannabis is rapidly expanding worldwide. Thus, innovative studies aimed to identify, understand and potentially reduce cannabis-evoked harms are warranted. Here, we found that ∆9-tetrahydrocannabinol, the psychoactive ingredient of cannabis, disrupts autophagy selectively in the striatum, a brain area that controls motor behavior, both in vitro and in vivo. Boosting autophagy, either pharmacologically (with temsirolimus) or by dietary intervention (with trehalose), rescued the ∆9-tetrahydrocannabinol-induced impairment of motor coordination in mice. The combination of conditional knockout mouse models and viral vector-mediated autophagy-modulating strategies in vivo showed that cannabinoid CB1 receptors located on neurons belonging to the direct (striatonigral) pathway are required for the motor-impairing activity of ∆9-tetrahydrocannabinol by inhibiting local autophagy. Taken together, these findings identify inhibition of autophagy as an unprecedented mechanistic link between cannabinoids and motor performance, and suggest that activators of autophagy might be considered as potential therapeutic tools to treat specific cannabinoid-evoked behavioral alterations. © Blázquez et al.
dc.description.sponsorshipRôle du récepteur aux cannabinoïdes de type 1 mitochondriale dans les circuits hypothalamiques et son interaction avec la voie mTORC1 dans l'obésité.en_US
dc.description.sponsorshipBordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043en_US
dc.description.sponsorshipReprésentation sensorielle lors d'états psychotiquesen_US
dc.description.sponsorshipRecepteurs aux cannabinoides dans le codage visuel corticalen_US
dc.description.sponsorshipRole du recepteur CB1 mitocondriel du tissue adipeux dans la regulation de la balance energetique - ANR-19-CE14-0039en_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enAutophagy
dc.subject.enCannabinoid
dc.subject.enDrug abuse
dc.subject.enmTOR
dc.subject.enMotor behaviour
dc.subject.enMouse
dc.subject.enNeuroscience
dc.subject.enStriatum
dc.title.enInhibition of striatonigral autophagy as a link between cannabinoid intoxication and impairment of motor coordination
dc.title.alternativeElifeen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.7554/ELIFE.56811en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed32773031en_US
dc.description.sponsorshipEuropeNeurocircuitry of endocannabinoid regulation of food intakeen_US
dc.description.sponsorshipEuropeDevelopment of pregnenolone derivatives as allosteric inhibitors of CB1 cannabinoid receptors for thetreatment of schizophrenia and psychotic syndromesen_US
bordeaux.journalElifeen_US
bordeaux.page1-24en_US
bordeaux.volume9en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCNRS
bordeaux.teamEndocannabinoïdes et Neuroadaptationen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDMinisterio de Ciencia, Innovación y Universidadesen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
bordeaux.identifier.funderIDHuman Frontier Science Programen_US
bordeaux.identifier.funderIDH2020 European Research Councilen_US
hal.exportfalse
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Elife&rft.date=2020-08-10&rft.volume=9&rft.spage=1-24&rft.epage=1-24&rft.au=BLAZQUEZ,%20Cristina&RUIZ-CALVO,%20Andrea&BAJO-GRANERAS,%20Raquel&BAUFRETON,%20Jerome%20M.&RESEL,%20Eva&rft.genre=article


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