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Precision-medicine findings from the FACE-SZ cohort to develop motivation-enhancing programs in real-world schizophrenia

dc.rights.licenseopenen_US
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierCentre d'études et de recherche sur les services de santé et la qualité de vie [CEReSS]
dc.contributor.authorKORCHIA, Theo
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierCentre d'études et de recherche sur les services de santé et la qualité de vie [CEReSS]
dc.contributor.authorTASTEVIN, Maud
hal.structure.identifierCentre d'études et de recherche sur les services de santé et la qualité de vie [CEReSS]
dc.contributor.authorSUNHARY DE VERVILLE, Pierre-Louis
dc.contributor.authorJOOBER, R.
dc.contributor.authorANDRIEU-HALLER, C.
dc.contributor.authorFAUGERE, Melanie
dc.contributor.authorGODIN, O.
dc.contributor.authorETCHECOPAR-ETCHART, D.
dc.contributor.authorBERNA, F.
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAOUIZERATE, Bruno
dc.contributor.authorCAPDEVIELLE, D.
dc.contributor.authorCHEREAU, I.
dc.contributor.authorCLAUSS-KOBAYASHI, J.
dc.contributor.authorCOULON, N.
dc.contributor.authorDOREY, J.-M.
dc.contributor.authorDUBERTRET, C.
dc.contributor.authorDUBREUCQ, J.
dc.contributor.authorMALLET, J.
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMISDRAHI, David
dc.contributor.authorPASSERIEUX, C.
dc.contributor.authorREY, R.
dc.contributor.authorSCHÜRHOFF, F.
dc.contributor.authorSZOKE, A.
dc.contributor.authorURBACH, M.
dc.contributor.authorLEBOYER, M.
dc.contributor.authorLLORCA, P.-M.
dc.contributor.authorLANÇON, C.
dc.contributor.authorRICHIERI, R.
dc.contributor.authorBOYER, L.
dc.contributor.authorFOND, G.
dc.date.accessioned2023-05-17T13:09:28Z
dc.date.available2023-05-17T13:09:28Z
dc.date.issued2022
dc.identifier.issn1562-2975en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182201
dc.description.abstractEnBackground: In people with schizophrenia, major areas of everyday life are impaired, including independent living, productive activities, social relationships and overall quality of life. Enhanced understanding of factors that hinder real-life functioning is vital for treatments to translate into more positive outcomes. Aim: The goal of the present study was to identify factors associated with motivation deficits in real-life schizophrenia, and to assess its contribution to impaired functioning and quality of life. Methods: Based on previous literature and clinical experience, several factors were selected and grouped into factors potentially explaining motivation deficits. Some of these variables were never investigated before in relationship with motivation deficits. Results: In 561 patients with schizophrenia of the national FACE-SZ cohort living in the community, 235 (41.9%) reported severe motivation deficits. These deficits were found to be significantly associated with impaired socially useful activities, psychological and physical quality of life (in almost all domains), alcohol use disorder (aOR = 2.141, p = 0.021), severe nicotine dependence (aOR = 2.906, p < 0.001) independently of age and sex. No significant association was found for body mass index, metabolic syndrome or physical activity level. In the second model, we identified the following modifiable factors associated with motivation deficits: history of suicide attempt (aOR = 2.297, p = 0.001), positive symptoms (aOR = 1.052, p = 0.006), current major depressive episode (aOR = 2.627, p < 0.001), sleep disorders (aOR = 1.474, p = 0.024) and lower medication adherence (aOR = 0.836, p = 0.001) independently of gender, current alcohol use disorder, second-generation antipsychotics and akathisia. No significant association was found for negative symptoms, childhood trauma and inflammation. These results were maintained after removing patients with schizoaffective disorders or those with major depressive disorder. Interpretation: Motivation deficits are frequent and remain persistent unmet need in real-world schizophrenia that should be addressed in future guidelines. Based on our results, literature and clinical experience, we recommend to address in priority major depression, sleep, suicide, positive symptoms (when present and as early as possible) and medication adherence to improve motivation deficits of schizophrenia. © 2022 Informa UK Limited, trading as Taylor & Francis Group.
dc.description.sponsorshipSorbonne Universités à Paris pour l'Enseignement et la Rechercheen_US
dc.description.sponsorshipFondaMental-Cohortes - ANR-10-COHO-0010en_US
dc.language.isoENen_US
dc.subject.enPsychiatry
dc.subject.enMental health
dc.subject.enPchizophrenia
dc.subject.enMood disorders
dc.subject.enDepressive disorders
dc.subject.enquality of life
dc.title.enPrecision-medicine findings from the FACE-SZ cohort to develop motivation-enhancing programs in real-world schizophrenia
dc.typeArticle de revueen_US
dc.identifier.doi10.1080/15622975.2022.2031286en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
bordeaux.journalWorld Journal of Biological Psychiatryen_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.institutionCNRS
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation FondaMentalen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=World%20Journal%20of%20Biological%20Psychiatry&amp;rft.date=2022&amp;rft.eissn=1562-2975&amp;rft.issn=1562-2975&amp;rft.au=KORCHIA,%20Theo&amp;TASTEVIN,%20Maud&amp;SUNHARY%20DE%20VERVILLE,%20Pierre-Louis&amp;JOOBER,%20R.&amp;ANDRIEU-HALLER,%20C.&amp;rft.genre=article


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