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Naproxen-bipyridine cocrystallization assisted by pressurized carbon dioxide

hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorERCICEK, Fatma
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorHARSCOAT-SCHIAVO, Christelle
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorLAYRISSE, Patrick
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorMARCHIVIE, Mathieu
hal.structure.identifierSciences et Méthodes Séparatives [SMS]
dc.contributor.authorCARTIGNY, Yohann
hal.structure.identifierSciences et Méthodes Séparatives [SMS]
dc.contributor.authorBRANDEL, Clément
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorTASSAING, Thierry
hal.structure.identifierTechnishe Universität Bergakademie Freiberg [TU Bergakademie Freiberg]
dc.contributor.authorCONRAD, Max
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorMARRE, Samuel
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorSUBRA-PATERNAULT, Pascale
dc.date.issued2023
dc.identifier.issn0896-8446
dc.description.abstractEnCocrystals of S-naproxen (S-NPX) or RS-naproxen (RS-NPX) and 4,4′bipyridine (BiPY) were prepared by the Gaseous Anti Solvent (GAS) method using CO2 as antisolvent. S-NPX and BiPY cocrystals were also produced by Cocrystallization with Supercritical Solvent (CSS) using CO2 as a solvent though leading to mixtures of cocrystals and homocrystals. Hydrogen-bond networks and stoichiometries of produced cocrystals were identical whatever the mode of preparation (evaporation, grinding and CO2-assisted processes) and matched those already described in literature: S-NPX2:BiPY1 and RS-NPX2:BiPY1. The effects of the NPX:BiPY molar ratio and of the processing conditions were investigated. By GAS, an excess of BiPY in the initial processed mixture was mandatory to produce pure S-NPX2:BiPY1 cocrystals whereas pure RS-NPX2:BiPY1 cocrystals were identically produced from mixtures of 2:2 and 2:1 NPX:BiPY initial ratio. No enrichment of the product in any of the naproxen enantiomer was reached, even when mixtures of S- + RS-NPX were coprocessed with bipyridine.
dc.description.sponsorshipApport du CO2 dans le contrôle de phase cristalline - ANR-18-CE07-0047
dc.language.isoen
dc.publisherElsevier
dc.subject.enCocrystal
dc.subject.enCO2
dc.subject.encrystallization
dc.subject.ennaproxen
dc.subject.enbipyridine
dc.subject.enantisolvent
dc.title.enNaproxen-bipyridine cocrystallization assisted by pressurized carbon dioxide
dc.typeArticle de revue
dc.identifier.doi10.1016/j.supflu.2023.105976
dc.subject.halChimie/Matériaux
dc.subject.halSciences du Vivant [q-bio]/Sciences pharmaceutiques/Pharmacie galénique
bordeaux.journalJournal of Supercritical Fluids
bordeaux.page105976
bordeaux.volume200
bordeaux.peerReviewedoui
hal.identifierhal-04098643
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-04098643v1
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