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Slow growing behavior in African trypanosomes during adipose tissue colonization

dc.rights.licenseopenen_US
dc.contributor.authorTRINDADE, Sandra
dc.contributor.authorDE NIZ, Mariana
dc.contributor.authorCOSTA-SEQUEIRA, Mariana
dc.contributor.authorBIZARRA-REBELO, Tiago
dc.contributor.authorBENTO, Fábio
dc.contributor.authorDEJUNG, Mario
dc.contributor.authorNARCISO, Marta Valido
dc.contributor.authorLÓPEZ-ESCOBAR, Lara
dc.contributor.authorFERREIRA, João
dc.contributor.authorBUTTER, Falk
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorBRINGAUD, Frederic
dc.contributor.authorGJINI, Erida
dc.contributor.authorFIGUEIREDO, Luisa
dc.date.accessioned2023-05-17T07:28:35Z
dc.date.available2023-05-17T07:28:35Z
dc.date.issued2022
dc.identifier.issn2041-1723en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182174
dc.description.abstractEnAbstract When Trypanosoma brucei parasites, the causative agent of sleeping sickness, colonize the adipose tissue, they rewire gene expression. Whether this adaptation affects population behavior and disease treatment remained unknown. By using a mathematical model, we estimate that the population of adipose tissue forms (ATFs) proliferates slower than blood parasites. Analysis of the ATFs proteome, measurement of protein synthesis and proliferation rates confirm that the ATFs divide on average every 12 h, instead of 6 h in the blood. Importantly, the population of ATFs is heterogeneous with parasites doubling times ranging between 5 h and 35 h. Slow-proliferating parasites remain capable of reverting to the fast proliferation profile in blood conditions. Intravital imaging shows that ATFs are refractory to drug treatment. We propose that in adipose tissue, a subpopulation of T. brucei parasites acquire a slow growing behavior, which contributes to disease chronicity and treatment failure.
dc.description.sponsorshipAlliance française contre les maladies parasitairesen_US
dc.description.sponsorshipInteractions métaboliques entre les adipocytes et les trypanosomes, un nouveau paradigme pour les trypanosomosesen_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.title.enSlow growing behavior in African trypanosomes during adipose tissue colonization
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41467-022-34622-wen_US
dc.subject.halSciences du Vivant [q-bio]/Microbiologie et Parasitologie/Parasitologieen_US
dc.subject.halSciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Génomique, Transcriptomique et Protéomique [q-bio.GN]en_US
bordeaux.journalNature Communicationsen_US
bordeaux.page7548en_US
bordeaux.volume13en_US
bordeaux.hal.laboratoriesMFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234en_US
bordeaux.issue1en_US
bordeaux.institutionCNRSen_US
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-03921010
hal.version1
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Communications&rft.date=2022&rft.volume=13&rft.issue=1&rft.spage=7548&rft.epage=7548&rft.eissn=2041-1723&rft.issn=2041-1723&rft.au=TRINDADE,%20Sandra&DE%20NIZ,%20Mariana&COSTA-SEQUEIRA,%20Mariana&BIZARRA-REBELO,%20Tiago&BENTO,%20F%C3%A1bio&rft.genre=article


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