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Association of omega 3 polyunsaturated fatty acids with incident chronic kidney disease: pooled analysis of 19 cohorts

dc.rights.licenseopenen_US
dc.contributor.authorONG, Kwok Leung
dc.contributor.authorMARKLUND, Matti
dc.contributor.authorHUANG, Liping
dc.contributor.authorRYE, Kerry-Anne
dc.contributor.authorHUI, Nicholas
dc.contributor.authorPAN, Xiong-Fei
dc.contributor.authorREBHOLZ, Casey M.
dc.contributor.authorKIM, Hyunju
dc.contributor.authorSTEFFEN, Lyn M.
dc.contributor.authorVAN WESTING, Anniek C.
dc.contributor.authorGELEIJNSE, Johanna M.
dc.contributor.authorHOOGEVEEN, Ellen K.
dc.contributor.authorCHEN, Yun-Yu
dc.contributor.authorCHIEN, Kuo-Liong
dc.contributor.authorFRETTS, Amanda M.
dc.contributor.authorLEMAITRE, Rozenn N.
dc.contributor.authorIMAMURA, Fumiaki
dc.contributor.authorFOROUHI, Nita G.
dc.contributor.authorWAREHAM, Nicholas J.
dc.contributor.authorBIRUKOV, Anna
dc.contributor.authorJAGER, Susanne
dc.contributor.authorKUXHAUS, Olga
dc.contributor.authorSCHULZE, Matthias B.
dc.contributor.authorDE MELLO, Vanessa Derenji
dc.contributor.authorTUOMILEHTO, Jaakko
dc.contributor.authorUUSITUPA, Matti
dc.contributor.authorLINDSTROM, Jaana
dc.contributor.authorTINTLE, Nathan
dc.contributor.authorHARRIS, William S.
dc.contributor.authorYAMASAKI, Keisuke
dc.contributor.authorHIRAKAWA, Yoichiro
dc.contributor.authorNINOMIYA, Toshiharu
dc.contributor.authorTANAKA, Toshiko
dc.contributor.authorFERRUCCI, Luigi
dc.contributor.authorBANDINELLI, Stefania
dc.contributor.authorVIRTANEN, Jyrki K.
dc.contributor.authorVOUTILAINEN, Ari
dc.contributor.authorJAYASENA, Tharusha
dc.contributor.authorTHALAMUTHU, Anbupalam
dc.contributor.authorPOLJAK, Anne
dc.contributor.authorBUSTAMANTE, Sonia
dc.contributor.authorSACHDEV, Perminder S.
dc.contributor.authorSENN, Mackenzie K.
dc.contributor.authorRICH, Stephen S.
dc.contributor.authorTSAI, Michael Y.
dc.contributor.authorWOOD, Alexis C.
dc.contributor.authorLAAKSO, Markku
dc.contributor.authorLANKINEN, Maria
dc.contributor.authorYANG, Xiaowei
dc.contributor.authorSUN, Liang
dc.contributor.authorLI, Huaixing
dc.contributor.authorLIN, Xu
dc.contributor.authorNOWAK, Christoph
dc.contributor.authorARNLOV, Johan
dc.contributor.authorRISERUS, Ulf
dc.contributor.authorLIND, Lars
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLE GOFF, Melanie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSAMIERI, Cecilia
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
dc.contributor.authorQIAN, Frank
dc.contributor.authorMICHA, Renata
dc.contributor.authorTIN, Adrienne
dc.contributor.authorKOTTGEN, Anna
dc.contributor.authorDE BOER, Ian H.
dc.contributor.authorSISCOVICK, David S.
dc.contributor.authorMOZAFFARIAN, Dariush
dc.contributor.authorWU, Jason Hy
dc.date.accessioned2023-05-15T09:46:04Z
dc.date.available2023-05-15T09:46:04Z
dc.date.issued2023-01-18
dc.identifier.issn1756-1833 (Electronic) 0959-8138 (Print)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182120
dc.description.abstractEnOBJECTIVE: To assess the prospective associations of circulating levels of omega 3 polyunsaturated fatty acid (n-3 PUFA) biomarkers (including plant derived α linolenic acid and seafood derived eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid) with incident chronic kidney disease (CKD). DESIGN: Pooled analysis. DATA SOURCES: A consortium of 19 studies from 12 countries identified up to May 2020. STUDY SELECTION: Prospective studies with measured n-3 PUFA biomarker data and incident CKD based on estimated glomerular filtration rate. DATA EXTRACTION AND SYNTHESIS: Each participating cohort conducted de novo analysis with prespecified and consistent exposures, outcomes, covariates, and models. The results were pooled across cohorts using inverse variance weighted meta-analysis. MAIN OUTCOME MEASURES: Primary outcome of incident CKD was defined as new onset estimated glomerular filtration rate <60 mL/min/1.73 m(2). In a sensitivity analysis, incident CKD was defined as new onset estimated glomerular filtration rate <60 mL/min/1.73 m(2) and <75% of baseline rate. RESULTS: 25 570 participants were included in the primary outcome analysis and 4944 (19.3%) developed incident CKD during follow-up (weighted median 11.3 years). In multivariable adjusted models, higher levels of total seafood n-3 PUFAs were associated with a lower incident CKD risk (relative risk per interquintile range 0.92, 95% confidence interval 0.86 to 0.98; P=0.009, I(2)=9.9%). In categorical analyses, participants with total seafood n-3 PUFA level in the highest fifth had 13% lower risk of incident CKD compared with those in the lowest fifth (0.87, 0.80 to 0.96; P=0.005, I(2)=0.0%). Plant derived α linolenic acid levels were not associated with incident CKD (1.00, 0.94 to 1.06; P=0.94, I(2)=5.8%). Similar results were obtained in the sensitivity analysis. The association appeared consistent across subgroups by age (≥60 v <60 years), estimated glomerular filtration rate (60-89 v ≥90 mL/min/1.73 m(2)), hypertension, diabetes, and coronary heart disease at baseline. CONCLUSIONS: Higher seafood derived n-3 PUFA levels were associated with lower risk of incident CKD, although this association was not found for plant derived n-3 PUFAs. These results support a favourable role for seafood derived n-3 PUFAs in preventing CKD.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.title.enAssociation of omega 3 polyunsaturated fatty acids with incident chronic kidney disease: pooled analysis of 19 cohorts
dc.title.alternativeBMJen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1136/bmj-2022-072909en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed36653033en_US
bordeaux.journalBMJen_US
bordeaux.volume380en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamACTIVE_BPHen_US
bordeaux.teamELEANOR_BPHen_US
bordeaux.teamLEHA_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04102401
hal.version1
hal.date.transferred2023-05-22T10:15:20Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=BMJ&amp;rft.date=2023-01-18&amp;rft.volume=380&amp;rft.eissn=1756-1833%20(Electronic)%200959-8138%20(Print)&amp;rft.issn=1756-1833%20(Electronic)%200959-8138%20(Print)&amp;rft.au=ONG,%20Kwok%20Leung&amp;MARKLUND,%20Matti&amp;HUANG,%20Liping&amp;RYE,%20Kerry-Anne&amp;HUI,%20Nicholas&amp;rft.genre=article


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