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dc.rights.licenseopenen_US
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorSOURIOUX, Melissa
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorBERTRAND, Sandrine
ORCID: 0000-0002-3020-7980
IDREF: 237520958
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorCAZALETS, Jean-Rene
ORCID: 0000-0001-9047-3933
IDREF: 032170149
dc.date.accessioned2023-05-12T12:35:06Z
dc.date.available2023-05-12T12:35:06Z
dc.date.issued2018-07-09
dc.identifier.issn1544-9173en_US
dc.identifier.urioai:crossref.org:10.1371/journal.pbio.2005460
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182085
dc.description.abstractEnHere, we investigated intrinsic spinal cord mechanisms underlying the physiological requirement for autonomic and somatic motor system coupling. Using an in vitro spinal cord preparation from newborn rat, we demonstrate that the specific activation of muscarinic cholinergic receptors (mAchRs) (with oxotremorine) triggers a slow burst rhythm in thoracic spinal segments, thereby revealing a rhythmogenic capability in this cord region. Whereas axial motoneurons (MNs) were rhythmically activated during both locomotor activity and oxotremorine-induced bursting, intermediolateral sympathetic preganglionic neurons (IML SPNs) exhibited rhythmicity solely in the presence of oxotremorine. This somato-sympathetic synaptic drive shared by MNs and IML SPNs could both merge with and modulate the locomotor synaptic drive produced by the lumbar motor networks. This study thus sheds new light on the coupling between somatic and sympathetic systems and suggests that an intraspinal network that may be conditionally activated under propriospinal cholinergic control constitutes at least part of the synchronizing mechanism.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.sourcecrossref
dc.title.enCholinergic-mediated coordination of rhythmic sympathetic and motor activities in the newborn rat spinal cord
dc.typeArticle de revueen_US
dc.identifier.doi10.1371/journal.pbio.2005460en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed29985914en_US
bordeaux.journalPLoS Biologyen_US
bordeaux.volume16en_US
bordeaux.hal.laboratoriesInstitut de neurosciences cognitives et intégratives d'Aquitaine (INCIA) - UMR 5287en_US
bordeaux.issue7en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.teamCoordination et plasticité des générateurs spinauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
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hal.exportfalse
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dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=PLoS%20Biology&rft.date=2018-07-09&rft.volume=16&rft.issue=7&rft.eissn=1544-9173&rft.issn=1544-9173&rft.au=SOURIOUX,%20Melissa&BERTRAND,%20Sandrine&CAZALETS,%20Jean-Rene&rft.genre=article


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