MFP (Laboratoire Microbiologie Fondamentale et Pathogénicité)

L'objectif du laboratoire de Microbiologie Fondamentale et Pathogénicité (MFP) est d'accroître les connaissances générales, scientifiques et fondamentales, sur les interactions entre des agents pathogènes (virus, bactéries, parasites et champignons) et leurs hôtes (mammifères et insectes vecteurs), liées à la réplication des microorganismes et au développement de la maladie. Le but final est de comprendre les conséquences des interactions moléculaires et métaboliques à différents niveaux, depuis les aspects les plus fondamentaux jusqu'à l’épidémiologie. Le laboratoire MFP est composé de 6 équipes dont les thèmes sont: "variabilité, réplication et mobilité des génomes viraux et bactériens", "dynamique intracellulaire des structures sous virales", "biogénèse du cytosquelette chez les trypanosomes", "métabolisme intermédiaire des trypanosomes", "Candida et pathogénicité" et "biologie moléculaire des machines bactériennes".

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MFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234

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Envíos recientes

Visualization of Trypanosoma brucei flagellar pocket collar biogenesis identifies two new cytoskeletal structures.

Mucosal passive immunization with monoclonal antibodies targeting Candidalysin and Hyr proteins attenuates vaginal candidiasis in mice.

Development of chimeric multivalent proteins for serological diagnosis of African animal trypanosomosis.

Novel Thiazolidinedione Derivatives as Potential ZIKV Antiviral Inhibitors.

Aquarius helicase facilitates HIV-1 integration into R-loop enriched genomic regions.

An Integrative Approach to Assessing the Impact of Mercury (Hg) on Avian Behaviour: From Molecule to Movement.

G-quadruplexes are promoter elements controlling nucleosome exclusion and RNA polymerase II pausing.

High-risk human papillomavirus cervical infection prevalence: a nationwide retrospective study comparing opportunistic and organised screening, France, 2020 to 2023

Isolation of New Chemical Modulators of the Interaction Between HIV-1 Integrase and the Cellular Restriction Factor GCN2.

Human Type-I Interferon Omega Holds Potent Antiviral Properties and Promotes Cytolytic CD8 T Cell Responses.

Lysosomal membrane permeabilization enhances the anticancer effects of POLR1 (RNA polymerase I) transcription inhibitors.

Interaction with eukaryotic cells enhances the circularization and transcription of integrative and conjugative elements in Mycoplasma hominis.

CXCL10-dependent epithelial-vascular cross-talk for endothelial activation following SARS-CoV-2 infection.

Clinical evaluation of two commercial PCR kits for the detection of nonviral sexually transmitted infections.

Real-time genome imaging of host interactions in adeno-associated virus genome release.

Timed chromatin invasion during mitosis governs prototype foamy virus integration site selection and infectivity.

The glycosomal ATP-dependent phosphofructokinase of Trypanosoma brucei operates also in the gluconeogenic direction.

LAVR-289, an Orally Bioavailable Inhibitor of Adenovirus Replication In Vitro and In Vivo

Advanced viral genome in vitro Cas9 editing (AdVICE): an overnight method for traceless and limitless manipulation of adenoviral and vector genomes with large transgenes

Doxycycline en prévention des infections sexuellement transmissibles, pratiques d’utilisation : revue narrative de la littérature

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MFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234

Listar por

Envíos recientes

Visualization of Trypanosoma brucei flagellar pocket collar biogenesis identifies two new cytoskeletal structures. ﻿

Mucosal passive immunization with monoclonal antibodies targeting Candidalysin and Hyr proteins attenuates vaginal candidiasis in mice. ﻿

Development of chimeric multivalent proteins for serological diagnosis of African animal trypanosomosis. ﻿

Novel Thiazolidinedione Derivatives as Potential ZIKV Antiviral Inhibitors. ﻿

Aquarius helicase facilitates HIV-1 integration into R-loop enriched genomic regions. ﻿

An Integrative Approach to Assessing the Impact of Mercury (Hg) on Avian Behaviour: From Molecule to Movement. ﻿

G-quadruplexes are promoter elements controlling nucleosome exclusion and RNA polymerase II pausing. ﻿

High-risk human papillomavirus cervical infection prevalence: a nationwide retrospective study comparing opportunistic and organised screening, France, 2020 to 2023 ﻿

Isolation of New Chemical Modulators of the Interaction Between HIV-1 Integrase and the Cellular Restriction Factor GCN2. ﻿

Human Type-I Interferon Omega Holds Potent Antiviral Properties and Promotes Cytolytic CD8 T Cell Responses. ﻿

Lysosomal membrane permeabilization enhances the anticancer effects of POLR1 (RNA polymerase I) transcription inhibitors. ﻿

Interaction with eukaryotic cells enhances the circularization and transcription of integrative and conjugative elements in Mycoplasma hominis. ﻿

CXCL10-dependent epithelial-vascular cross-talk for endothelial activation following SARS-CoV-2 infection. ﻿

Clinical evaluation of two commercial PCR kits for the detection of nonviral sexually transmitted infections. ﻿

Real-time genome imaging of host interactions in adeno-associated virus genome release. ﻿

Timed chromatin invasion during mitosis governs prototype foamy virus integration site selection and infectivity. ﻿

The glycosomal ATP-dependent phosphofructokinase of Trypanosoma brucei operates also in the gluconeogenic direction. ﻿

LAVR-289, an Orally Bioavailable Inhibitor of Adenovirus Replication In Vitro and In Vivo ﻿

Advanced viral genome in vitro Cas9 editing (AdVICE): an overnight method for traceless and limitless manipulation of adenoviral and vector genomes with large transgenes ﻿

Doxycycline en prévention des infections sexuellement transmissibles, pratiques d’utilisation : revue narrative de la littérature ﻿