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Microrheology and structural quantification of hypercoagulable clots

dc.rights.licenseopenen_US
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorWOLFF-TROMBINI, L
hal.structure.identifierMathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine [M3DISIM]
dc.contributor.authorCERIPA, A
hal.structure.identifierLaboratoire Charles Fabry [LCF]
dc.contributor.authorMOREAU, J
hal.structure.identifierService d'hématologie biologique
dc.contributor.authorGALINAT, H
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorJAMES, C
hal.structure.identifierLaboratoire Charles Fabry [LCF]
dc.contributor.authorWESTBROOK, N
hal.structure.identifierMathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine [M3DISIM]
dc.contributor.authorALLAIN, J
dc.date.accessioned2023-04-06T13:39:24Z
dc.date.available2023-04-06T13:39:24Z
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/172847
dc.description.abstractEnWe propose a combination of microrheological and structural characterizations of fibrin networks to study blood hypercoagulability. Fibrin is the central element of coagulation as its polymerization creates the network of fibers in which platelets and red blood cells are included. This is a controlled process via cascades between various coagulation factors. An alteration in the concentrations of coagulation factors and inhibitors will lead to hypocoagulation or hypercoagulation. These changes in the conditions of polymerization of fibrin lead to the formation of networks with different architectures and thus modify its mechanical behavior. We have performed microrheology by recording Brownian motion of microbeads caught in the network of clots. The structure was quantified under the same polymerization conditions with confocal microscopy images. We have tested our approach by adding fibrinogen to the plasma, which leads to a stiffer, denser network with shorter fibers. The addition of coagulation Factor VIII at 400% induces the same correlated trend between a denser network and a higher modulus. This comparative approach is promising for the study of other conditions altering clot formation and may lead to a new diagnosis approach for hypercoagulability.
dc.description.sponsorshipImagerie et reconstruction multiéchelles de la morphogenèse. (Plateforme d'innovation technologique et méthodologique pour l'imagerie in vivo et la reconstruction des dynamiques multiéchelles de la morphogenèse) - ANR-11-EQPX-0029en_US
dc.language.isoENen_US
dc.title.enMicrorheology and structural quantification of hypercoagulable clots
dc.typeDocument de travail - Pré-publicationen_US
dc.subject.halPhysique [physics]/Physique [physics]/Biophysique [physics.bio-ph]en_US
dc.identifier.arxiv2304.00812en_US
bordeaux.hal.laboratoriesBiologie des maladies cardiovasculaires (BMC) - UMR 1034en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.import.sourcehal
hal.identifierhal-04054272
hal.version1
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.au=WOLFF-TROMBINI,%20L&CERIPA,%20A&MOREAU,%20J&GALINAT,%20H&JAMES,%20C&rft.genre=preprint


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