HERRY, Cyril; JERCOG, Daniel

doi:10.1016/j.conb.2022.102600

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HERRY, Cyril

Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

JERCOG, Daniel
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

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Article de revue

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Current Opinion in Neurobiology. 2022-10, vol. 76, p. 102600

Resumen en inglés

Our understanding of the neuronal circuits and mechanisms of defensive systems has been primarily dominated by studies focusing on the contribution of individual cells in the processing of threat-predictive cues, defensive responses, the extinction of such responses and the contextual modulation of threat-related behavior. These studies have been key in establishing threat-related circuits and mechanisms. Yet, they fall short in answering long-standing questions related to the integrative processing of distinct threatening cues, behavioral states induced by threat-related events, or the bridging from sensory processing of threat-related cues to specific defensive responses. Recent conceptual and technical developments has allowed the monitoring of large populations of neurons, which in addition to advanced analytic tools, have improved our understanding of how collective neuronal activity supports threat-related behaviors. In this review, we discuss the current knowledge of neuronal population codes within threat-related networks, in the context of aversive motivated behavior and the study of defensive systems.< Leer menos

Palabras clave en inglés

Behavioral neurophysiology

Defensive behaviors

Machine learning

Population coding

Systems neuroscience

URI

https://oskar-bordeaux.fr/handle/20.500.12278/172738

DOI

http://dx.doi.org/10.1016/j.conb.2022.102600

Proyecto ANR

Innovations instrumentales et procédurales en psychopathologie expérimentale chez le rongeur - ANR-10-EQPX-0008

Centros de investigación

Neurocentre Magendie - U1215