Despite the development and application of new digital solutions in the production industry, the human operator is still essential in the production chain monitoring and control processes. In this context, some activities can be crucial for the human operator like, for example, drift diagnosis in production control process. It requires attention and experience and can be assisted by Decision Support System (DSS) to guide operators indecision-making in industrial production process control. Drift diagnosis process is a challenging problem in this context and artificial intelligence technologies are promising to tackle this issue. In this paper, we propose a new approach of DSS for drift diagnosis. The proposed approach is built upon a literature review on drift concept, drift detection methods and failure diagnosis approaches. This multi-model approach is designedto address all the diagnostics tasks of production systems and is based on Machine Learning (ML) algorithms to model the behavior of production systems, a knowledge-based model to integrate human experiences and a data-driven model to combine historical data from sensors. When the drift occurs, the proposed DSS can help human operator to determine drift causes and to suggest corrective actions. This article also provides guidelines about the design of a decision support system to support human operators in complex decision activities.Read less <