Urine Protein/Creatinine Ratio in Thrombotic Microangiopathies: A Simple Test to Facilitate Thrombotic Thrombocytopenic Purpura and Hemolytic and Uremic Syndrome Diagnosis
| dc.rights.license | open | en_US |
| dc.contributor.author | BURGUET, Laure | |
| hal.structure.identifier | Institut de Mathématiques de Bordeaux [IMB] | |
| dc.contributor.author | TATON, Benjamin | |
| dc.contributor.author | PREZELIN-REYDIT, Mathilde | |
| hal.structure.identifier | Bioingénierie tissulaire [BIOTIS] | |
| dc.contributor.author | RUBIN, Sebastien | |
| dc.contributor.author | PICARD, Walter | |
| dc.contributor.author | GRUSON, Didier | |
| dc.contributor.author | RYMAN, Anne | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation [ImmunoConcept] | |
| dc.contributor.author | CONTIN BORDES, Cecile | |
| dc.contributor.author | COPPO, Paul | |
| hal.structure.identifier | Bioingénierie tissulaire [BIOTIS] | |
| dc.contributor.author | COMBE, Christian | |
| dc.contributor.author | DELMAS, Yahsou | |
| dc.date.accessioned | 2023-04-04T09:45:49Z | |
| dc.date.available | 2023-04-04T09:45:49Z | |
| dc.date.issued | 2022-01 | |
| dc.identifier.issn | 2077-0383 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/172719 | |
| dc.description.abstractEn | Background: Early diagnosis of thrombotic thrombocytopenic purpura (TTP) versus hemolytic and uremic syndrome (HUS) is critical for the prompt initiation of specific therapies. Objective: To evaluate the diagnostic performance of the proteinuria/creatininuria ratio (PU/CU) for TTP versus HUS. Patients/Methods: In a retrospective study, in association with the “French Score” (FS) (platelets < 30 G/L and serum creatinine level < 200 µmol/L), we assessed PU/CU for the diagnosis of TTP in patients above the age of 15 with thrombotic microangiopathy (TMA). Patients with a history of kidney disease or with on-going cancer, allograft or pregnancy were excluded from the analysis. Results: Between February 2011 and April 2019, we identified 124 TMA. Fifty-six TMA patients for whom PU/CU were available, including 35 TTP and 21 HUS cases, were considered. Using receiver–operating characteristic curves (ROC), those with a threshold of 1.5 g/g for the PU/CU had a 77% sensitivity (95% CI (63, 94)) and a 90% specificity (95% CI (71, 100)) for TTP diagnosis compared with those having an 80% sensitivity (95% CI (66, 92)) and a 90% specificity (95% CI (76, 100) with a FS of 2. In comparison, a composite score, defined as a FS of 2 or a PU/CU ≤ 1.5 g/g, improved sensitivity to 99.6% (95% CI (93, 100)) for TTP diagnosis and enabled us to reclassify seven false-negative TTP patients. Conclusions: The addition of urinary PU/CU upon admission of patients with TMA is a fast and readily available test that can aid in the differential diagnosis of TTP versus HUS alongside traditional scoring. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | diagnosis | |
| dc.subject.en | differential | |
| dc.subject.en | hemolytic-uremic syndrome | |
| dc.subject.en | proteinuria | |
| dc.subject.en | purpura | |
| dc.subject.en | thrombotic microangiopathies | |
| dc.subject.en | thrombotic thrombocytopenic | |
| dc.title.en | Urine Protein/Creatinine Ratio in Thrombotic Microangiopathies: A Simple Test to Facilitate Thrombotic Thrombocytopenic Purpura and Hemolytic and Uremic Syndrome Diagnosis | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3390/jcm11030648 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie | en_US |
| bordeaux.journal | Journal of clinical medicine | en_US |
| bordeaux.volume | 11 | en_US |
| bordeaux.hal.laboratories | Bioingénierie Tissulaire (BioTis) - U1026 | en_US |
| bordeaux.issue | 3 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.institution | CHU de Bordeaux | en_US |
| bordeaux.institution | Institut Bergonié | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-04057640 | |
| hal.version | 1 | |
| hal.date.transferred | 2023-04-04T09:45:53Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20clinical%20medicine&rft.date=2022-01&rft.volume=11&rft.issue=3&rft.eissn=2077-0383&rft.issn=2077-0383&rft.au=BURGUET,%20Laure&TATON,%20Benjamin&PREZELIN-REYDIT,%20Mathilde&RUBIN,%20Sebastien&PICARD,%20Walter&rft.genre=article |
