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Development of a vascular substitute produced by weaving yarn made from human amniotic membrane

dc.rights.licenseopenen_US
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorGREMARE, Agathe
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorTHIBES, Lisa
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorGLUAIS, Maude
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorTORRES, Yoann
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorPOTART, Diane
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorSILVA, Nicolas Da
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorDUSSERRE, Nathalie
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorFENELON, Mathilde
dc.contributor.authorSENTILHES, Loïc
hal.structure.identifierBordeaux Imaging Center [BIC]
dc.contributor.authorLACOMME, Sabrina
hal.structure.identifierBordeaux Imaging Center [BIC]
dc.contributor.authorSVAHN, Isabelle
hal.structure.identifierBordeaux Imaging Center [BIC]
dc.contributor.authorGONTIER, Etienne
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorFRICAIN, Jean-Christophe
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorL’HEUREUX, Nicolas
dc.date.accessioned2023-04-04T09:31:38Z
dc.date.available2023-04-04T09:31:38Z
dc.date.issued2022-08
dc.identifier.issn1758-5090en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/172715
dc.description.abstractEnBecause synthetic vascular prostheses perform poorly in small-diameter revascularization, biological vascular substitutes are being developed as an alternative. Although their in vivo results are promising, their production involves long, complex, and expensive tissue engineering methods. To overcome these limitations, we propose an innovative approach that combines the human amniotic membrane (HAM), which is a widely available and cost-effective biological raw material, with a rapid and robust textile-inspired assembly strategy. Fetal membranes were collected after cesarean deliveries at term. Once isolated by dissection, HAM sheets were cut into ribbons that could be further processed by twisting into threads. Characterization of the HAM yarns (both ribbons and threads) showed that their physical and mechanical properties could be easily tuned. Since our clinical strategy will be to provide an off-the-shelf allogeneic implant, we studied the effects of decellularization and/or gamma sterilization on the histological, mechanical, and biological properties of HAM ribbons. Gamma irradiation of hydrated HAMs, with or without decellularization, did not interfere with the ability of the matrix to support endothelium formation in vitro. Finally, our HAM-based, woven tissue-engineered vascular grafts (TEVGs) exhibited clinically relevant mechanical properties. Thus, this study demonstrates that human, completely biological, allogeneic, small-diameter TEVGs can be produced from HAM, thereby avoiding costly cell culture and bioreactors.
dc.description.sponsorshipDéveloppment d'une infrastructure française distribuée coordonnée - ANR-10-INBS-0004en_US
dc.language.isoENen_US
dc.subject.enamniotic membrane
dc.subject.envascular graft
dc.subject.entissue engineering
dc.subject.enhuman textiles
dc.title.enDevelopment of a vascular substitute produced by weaving yarn made from human amniotic membrane
dc.title.alternativeBiofabricationen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1088/1758-5090/ac84aeen_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
bordeaux.journalBiofabricationen_US
bordeaux.volume14en_US
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCHU de Bordeauxen_US
bordeaux.institutionInstitut Bergoniéen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04057592
hal.version1
hal.date.transferred2023-04-04T09:31:41Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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