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Perioperative individualized hemodynamic optimization according to baseline mean arterial pressure in cardiac surgery patients: Rationale and design of the OPTIPAM randomized trial

dc.rights.licenseopenen_US
dc.contributor.authorDESCAMPS, Richard
hal.structure.identifierCHU Pitié-Salpêtrière [AP-HP]
dc.contributor.authorAMOUR, Julien
hal.structure.identifierCHU Rouen
hal.structure.identifierEndothélium, valvulopathies et insuffisance cardiaque [EnVI]
dc.contributor.authorBESNIER, Emmanuel
hal.structure.identifierCHU Pitié-Salpêtrière [AP-HP]
dc.contributor.authorBOUGLE, Adrien
hal.structure.identifierClinique Pasteur [Toulouse]
dc.contributor.authorCHARBONNEAU, Hélène
hal.structure.identifierPôle de Médecine Périopératoire [CHU Clermont-Ferrand]
dc.contributor.authorCHARVIN, Martin
hal.structure.identifierInnovations thérapeutiques en hémostase = Innovative Therapies in Haemostasis [IThEM - U1140]
hal.structure.identifierHôpital Européen Georges Pompidou [APHP] [HEGP]
dc.contributor.authorCHOLLEY, Bernard
hal.structure.identifierClinique de la Sauvegarde [Lyon]
dc.contributor.authorDESEBBE, Olivier
hal.structure.identifierHôpital Louis Pradel [CHU - HCL]
hal.structure.identifierCardiovasculaire, métabolisme, diabétologie et nutrition [CarMeN]
dc.contributor.authorFELLAHI, Jean-Luc
hal.structure.identifierMethodS in Patients-centered outcomes and HEalth ResEarch [SPHERE]
hal.structure.identifierCentre hospitalier universitaire de Poitiers = Poitiers University Hospital [CHU de Poitiers [La Milétrie]]
dc.contributor.authorFRASCA, Denis
hal.structure.identifierFranco-czech Laboratory for clinical research on obesity
hal.structure.identifierCentre Hospitalier Universitaire de Toulouse [CHU Toulouse]
dc.contributor.authorLABASTE, François
dc.contributor.authorLENA, Diane
hal.structure.identifierCHU Amiens-Picardie
hal.structure.identifierSimplification des soins chez les patients complexes - UR UPJV 7518 [SSPC]
dc.contributor.authorMAHJOUB, Yazine
hal.structure.identifierCentre Hospitalier Universitaire [Strasbourg] [CHU Strasbourg]
dc.contributor.authorMERTES, Paul-Michel
hal.structure.identifierCentre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] [CHU ST-E]
dc.contributor.authorMOLLIEX, Serge
dc.contributor.authorMOURI, Pierre-Henry
hal.structure.identifierCentre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
dc.contributor.authorMOUSSA, Mouhamed Djahoum
hal.structure.identifierCentre Hospitalier Régional Universitaire de Brest [CHRU Brest]
dc.contributor.authorOILLEAU, Jean-Ferreol
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
hal.structure.identifierCHU Bordeaux
dc.contributor.authorOUATTARA, Alexandre
hal.structure.identifierService d'anesthésie - réanimation chirurgicale [CHU Bichat]
dc.contributor.authorPROVENCHERE, Sophie
dc.contributor.authorROZEC, Bertand
dc.contributor.authorPARIENTI, Jean-Jacques
dc.contributor.authorFISCHER, Marc-Olivier
dc.date.accessioned2023-03-30T12:02:42Z
dc.date.available2023-03-30T12:02:42Z
dc.date.issued2023-03
dc.identifier.issn0002-8703en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/172663
dc.description.abstractEnBackground: Postoperative morbidity and mortality after cardiac surgery with cardiopulmonary bypass (CPB) remain high despite recent advances in both anesthesia and perioperative management. Among modifiable risk factors for postoperative complications, optimal arterial pressure during and after surgery has been under debate for years. Recent data suggest that optimizing arterial pressure to the baseline of the patient may improve outcomes. We hypothesize that optimizing the mean arterial pressure (MAP) to the baseline MAP of the patient during cardiac surgery with CPB and during the first 24 hours postoperatively may improve outcomes.Study design: The OPTIPAM trial (NCT05403697) will be a multicenter, randomized, open-label controlled trial testing the superiority of optimized MAP management as compared with a MAP of 65mmHg or more during both the intraoperative and postoperative periods in 1100 patients scheduled for cardiac surgery with CPB. The primary composite end point is the occurrence of acute kidney injury, neurological complications including stroke or postoperative delirium, and death. The secondary endpoints are hospital and intensive care unit lengths of stay, Day 7 and Day 90 mortality, postoperative cognitive dysfunction on Day 7 and Day 90, and quality of life at Day 7 and Day 90. An interim analysis will assess the safety of the intervention.Conclusion: The OPTIPAM trial will assess the effectiveness of an individualized target of mean arterial pressure in cardiac surgery with CPB in reducing postoperative morbidity.
dc.language.isoENen_US
dc.subject.enArterial pressure
dc.subject.enCardiac surgery
dc.subject.enHemodynamic optimization
dc.title.enPerioperative individualized hemodynamic optimization according to baseline mean arterial pressure in cardiac surgery patients: Rationale and design of the OPTIPAM randomized trial
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.ahj.2023.03.005en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
bordeaux.journalAmerican Heart Journalen_US
bordeaux.hal.laboratoriesBiologie des maladies cardiovasculaires (BMC) - UMR 1034en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-04044174
hal.version1
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
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