Altered functional brain states predict cognitive decline 5 years after a clinically isolated syndrome
| dc.rights.license | open | en_US |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | KOUBIYR, Ismail | |
| hal.structure.identifier | Department of Anatomy and Neurosciences, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam | |
| dc.contributor.author | BROEDERS, Tommy A.A | |
| hal.structure.identifier | CHU Bordeaux | |
| dc.contributor.author | DELOIRE, Mathilde | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | BROCHET, Bruno | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | TOURDIAS, Thomas | |
| hal.structure.identifier | Department of Anatomy and Neurosciences, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam | |
| dc.contributor.author | GEURTS, Jeroen J.G. | |
| hal.structure.identifier | Department of Anatomy and Neurosciences, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam | |
| dc.contributor.author | SCHOONHEIM, Menno Michiel | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | RUET, Aurelie | |
| dc.date.accessioned | 2023-03-24T08:24:21Z | |
| dc.date.available | 2023-03-24T08:24:21Z | |
| dc.date.issued | 2022-10 | |
| dc.identifier.issn | 1352-4585 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/172412 | |
| dc.description.abstractEn | Background: Cognitive impairment occurs in the earliest stages of multiple sclerosis (MS) together with altered functional connectivity (FC). Objective: The aim of this study was to investigate the evolution of dynamic FC states in early MS and their role in shaping cognitive decline. Methods: Overall, 32 patients were enrolled after their first neurological episode suggestive of MS and underwent cognitive evaluation and resting-state functional MRI (fMRI) over 5 years. In addition, 28 healthy controls were included at baseline. Results: Cognitive performance was stable during the first year and declined after 5 years. At baseline, the number of transitions between states was lower in MS compared to controls (p = 0.01). Over time, frequency of high FC states decreased in patients (p = 0.047) and increased in state with low FC (p = 0.035). Cognitive performance at Year 5 was best predicted by the mean connectivity of high FC state at Year 1. Conclusion: Patients with early MS showed reduced functional network dynamics at baseline. Longitudinal changes showed longer time spent in a state of low FC but less time spent and more connectivity disturbance in more integrative states with high within- and between-network FC. Disturbed FC within this more integrative state was predictive of future cognitive decline. © The Author(s), 2022. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | CIS | |
| dc.subject.en | Multiple sclerosis | |
| dc.subject.en | Cognition | |
| dc.subject.en | Dynamic FC | |
| dc.subject.en | fMRI | |
| dc.subject.en | Longitudinal | |
| dc.subject.en | Functional magnetic resonance imaging | |
| dc.title.en | Altered functional brain states predict cognitive decline 5 years after a clinically isolated syndrome | |
| dc.title.alternative | Mult Scler. | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1177/13524585221101470 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 35735004 | en_US |
| bordeaux.journal | Multiple Sclerosis Journal | en_US |
| bordeaux.page | 1973-1982 | en_US |
| bordeaux.volume | 28 | en_US |
| bordeaux.hal.laboratories | Neurocentre Magendie - U1215 | en_US |
| bordeaux.issue | 12 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | Relations glie-neurone | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-04043980 | |
| hal.version | 1 | |
| hal.date.transferred | 2023-03-24T08:24:33Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Multiple%20Sclerosis%20Journal&rft.date=2022-10&rft.volume=28&rft.issue=12&rft.spage=1973-1982&rft.epage=1973-1982&rft.eissn=1352-4585&rft.issn=1352-4585&rft.au=KOUBIYR,%20Ismail&BROEDERS,%20Tommy%20A.A&DELOIRE,%20Mathilde&BROCHET,%20Bruno&TOURDIAS,%20Thomas&rft.genre=article |
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