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dc.rights.licenseopenen_US
dc.contributor.authorOMAR, Mahmoud Mohamed
dc.contributor.authorKISELEVA, Mariia
dc.contributor.authorLAPRISE-PELLETIER, Myriam
dc.contributor.authorAUGE, Amelie
dc.contributor.authorTUDURI, Ludovic
dc.contributor.authorFORTIN, Marc-André
dc.date.accessioned2023-03-17T13:21:14Z
dc.date.available2023-03-17T13:21:14Z
dc.date.issued2022-12-06
dc.identifier.issn0034-6748en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/172344
dc.description.abstractEnDiffusion cells are devices made of donor and acceptor compartments (DC and AC), separated by a membrane. They are widely used in pharmaceutical, cosmetic, toxicology, and protective equipment tests (e.g., gloves) to measure the kinetics of permeants (molecules and nanoparticles) across biological membranes as the skin. However, rarely is the concentration of permeants in the AC measured in continuous or in real-time, and this limitation leads to significant discrepancies in the calculations of kinetic parameters that define the permeation mechanisms. In this study, a diffusion cell compatible with positron emission tomography was used to measure the permeation kinetics of nanoparticles across glove membranes. The technology allows for the measurement of nanoparticle concentration in real-time in the two compartments (DC and AC) and at a detection sensitivity several orders of magnitude higher compared with conventional spectroscopies, thus allowing a much more precise extraction of kinetic parameters. Ultra-small (<10 nm) gold nanoparticles were used as a model nanoparticle contaminant. They were radiolabeled, and their diffusion kinetics was measured in continuous through latex and nitrile polymer membranes. Permeation profiles were recorded at sub-nanomolar sensitivity and in real-time, thus allowing the high precision extraction of kinetic permeation parameters. The technology, methodology, and data extraction process developed in this work could be applied to measure in real-time the kinetics of diffusion of a whole range of potentially toxic molecules and nanoparticles across polymer membranes, including glove membranes.
dc.language.isoENen_US
dc.title.enHigh sensitivity detection of nanoparticles permeation through polymer membranes: A physico-chemical and nuclear imaging measurement approach
dc.typeArticle de revueen_US
dc.identifier.doi10.1063/5.0087704en_US
dc.subject.halSciences de l'environnementen_US
bordeaux.journalReview of Scientific Instrumentsen_US
bordeaux.volume93en_US
bordeaux.hal.laboratoriesEPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805en_US
bordeaux.issue12en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.teamLPTCen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04034395
hal.version1
hal.date.transferred2023-03-17T13:21:21Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Review%20of%20Scientific%20Instruments&amp;rft.date=2022-12-06&amp;rft.volume=93&amp;rft.issue=12&amp;rft.eissn=0034-6748&amp;rft.issn=0034-6748&amp;rft.au=OMAR,%20Mahmoud%20Mohamed&amp;KISELEVA,%20Mariia&amp;LAPRISE-PELLETIER,%20Myriam&amp;AUGE,%20Amelie&amp;TUDURI,%20Ludovic&amp;rft.genre=article


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