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Female sex hormones and symptoms of obstructive sleep apnea in European women of a population-based cohort

dc.rights.licenseopenen_US
dc.contributor.authorSIGURDARDOTTIR, Erla S.
dc.contributor.authorGISLASON, Thorarinn
dc.contributor.authorBENEDIKTSDOTTIR, Bryndis
dc.contributor.authorHUSTAD, Steinar
dc.contributor.authorDADVAND, Payam
dc.contributor.authorDEMOLY, Pascal
dc.contributor.authorFRANKLIN, Karl A.
dc.contributor.authorHEINRICH, Joachim
dc.contributor.authorHOLM, Mathias
dc.contributor.authorVAN DER PLAAT, Diana A.
dc.contributor.authorJOGI, Rain
dc.contributor.authorLEYNAERT, Benedicte
dc.contributor.authorLINDBERG, Eva
dc.contributor.authorMARTINEZ-MORATALLA, Jesus
dc.contributor.authorAJA, Leire Sainz De
dc.contributor.authorPESCE, Giancarlo
dc.contributor.authorPIN, Isabelle
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRAHERISON-SEMJEN, Chantal
dc.contributor.authorPEREIRA-VEGA, Antonio
dc.contributor.authorREAL, Francisco Gomez
dc.contributor.authorTRIEBNER, Kai
dc.date.accessioned2023-03-14T07:57:30Z
dc.date.available2023-03-14T07:57:30Z
dc.date.issued2022-06-22
dc.identifier.issn1932-6203en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/172280
dc.description.abstractEnBackground The prevalence of obstructive sleep apnea is higher in women after menopause. This is suggested to be a result of an altered sex hormone balance but has so far not been confirmed in a population-based study. Objective To investigate whether serum concentration of estrogens and progesterone are associated with the prevalence of sleep apnea symptoms in middle-aged women of the general population. Methods We analyzed data from 774 women (40–67 years) from 15 study centers in seven countries participating in the second follow-up of the European Community Respiratory Health Survey (2010–2012). Multiple logistic regression models were fitted with self-reported symptoms of sleep apnea as outcomes and serum concentrations of various estrogens and progesterone as predictors. All analyses were adjusted for relevant covariates including age, BMI, education, study center, smoking habits, and reproductive age. Results Among all included women, a doubling of serum concentrations of estrone and progesterone was associated with 19% respectively 9% decreased odds of snoring. Among snorers, a doubling of the concentrations of 17β-estradiol, estrone and estrone 3-sulfate was associated with 18%, 23% and 17% decreased odds of breathing irregularly, and a doubling of the progesterone concentration was further associated with 12% decreased odds of waking up suddenly with a chocking sensation. Other evaluated associations were not statistically significant. Conclusions Middle-aged women with low serum estrogen and progesterone levels are more likely to snore and report symptoms of obstructive sleep apnea.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enAntioxidants
dc.subject.enBreathing
dc.subject.enEstrogens
dc.subject.enHormone replacement therapy
dc.subject.enMenopause
dc.subject.enProgesterone
dc.subject.enSex hormones
dc.subject.enSleep apnea
dc.title.enFemale sex hormones and symptoms of obstructive sleep apnea in European women of a population-based cohort
dc.typeArticle de revueen_US
dc.identifier.doi10.1371/journal.pone.0269569en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed35731786en_US
bordeaux.journalPLoS ONEen_US
bordeaux.volume17en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue6en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEPICENE_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=PLoS%20ONE&rft.date=2022-06-22&rft.volume=17&rft.issue=6&rft.eissn=1932-6203&rft.issn=1932-6203&rft.au=SIGURDARDOTTIR,%20Erla%20S.&GISLASON,%20Thorarinn&BENEDIKTSDOTTIR,%20Bryndis&HUSTAD,%20Steinar&DADVAND,%20Payam&rft.genre=article


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