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T Cell Immunogenicity, Gene Expression Profile, and Safety of Four Heterologous Prime-Boost Combinations of HIV Vaccine Candidates in Healthy Volunteers: Results of the Randomized Multi-Arm Phase I/II ANRS VRI01 Trial

dc.rights.licenseopenen_US
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRICHERT, Laura
dc.contributor.authorLELIEVRE, Jean Daniel
dc.contributor.authorLACABARATZ, Christine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHARDEL, Lucile
dc.contributor.authorHOCINI, Hakim
dc.contributor.authorWIEDEMANN, Aurelie
dc.contributor.authorLUCHT, Frederic
dc.contributor.authorPOIZOT-MARTIN, Isabelle
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBAUDUIN, Claire
dc.contributor.authorDIALLO, Alpha
dc.contributor.authorRIEUX, Veronique
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorROUCH, Elodie
dc.contributor.authorSURENAUD, Mathieu
dc.contributor.authorLEFEBVRE, Cecile
dc.contributor.authorFOUCAT, Emile
dc.contributor.authorTISSERAND, Pascaline
dc.contributor.authorGUILLAUMAT, Lydia
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDURAND, Melany
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHEJBLUM, Boris
ORCID: 0000-0003-0646-452X
IDREF: 189970316
dc.contributor.authorLAUNAY, Odile
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTHIEBAUT, Rodolphe
dc.contributor.authorLEVY, Yves
dc.date.accessioned2023-03-13T14:39:02Z
dc.date.available2023-03-13T14:39:02Z
dc.date.issued2022-06-15
dc.identifier.issn0022-1767en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/172274
dc.description.abstractEnHeterologous prime-boost strategies are of interest for HIV vaccine development. The order of prime-boost components could be important for the induction of T cell responses. In this phase I/II multi-arm trial, three vaccine candidates were used as prime or boost: modified vaccinia Ankara (MVA) HIV-B (coding for Gag, Pol, Nef); HIV LIPO-5 (five lipopeptides from Gag, Pol, Nef); DNA GTU-MultiHIV B (coding for Rev, Nef, Tat, Gag, Env gp160 clade B). Healthy human volunteers (n = 92) were randomized to four groups: 1) MVA at weeks 0/8 + LIPO-5 at weeks 20/28 (M/L); 2) LIPO-5 at weeks 0/8 + MVA at weeks 20/28 (L/M); 3) DNA at weeks 0/4/12 + LIPO-5 at weeks 20/28 (G/L); 4) DNA at weeks 0/4/12 + MVA at weeks 20/28 (G/M). The frequency of IFN-γ–ELISPOT responders at week 30 was 33, 43, 0, and 74%, respectively. Only MVA-receiving groups were further analyzed (n = 62). Frequency of HIV-specific cytokine-positive (IFN-γ, IL-2, or TNF-α) CD4+ T cells increased significantly from week 0 to week 30 (median change of 0.06, 0.11, and 0.10% for M/L, L/M, and G/M, respectively), mainly after MVA vaccinations, and was sustained until week 52. HIV-specific CD8+ T cell responses increased significantly at week 30 in M/L and G/M (median change of 0.02 and 0.05%). Significant whole-blood gene expression changes were observed 2 wk after the first MVA injection, regardless of its use as prime or boost. An MVA gene signature was identified, including 86 genes mainly related to cell cycle pathways. Three prime-boost strategies led to CD4+ and CD8+ T cell responses and to a whole-blood gene expression signature primarily due to their MVA HIV-B component.
dc.language.isoENen_US
dc.title.enT Cell Immunogenicity, Gene Expression Profile, and Safety of Four Heterologous Prime-Boost Combinations of HIV Vaccine Candidates in Healthy Volunteers: Results of the Randomized Multi-Arm Phase I/II ANRS VRI01 Trial
dc.typeArticle de revueen_US
dc.identifier.doi10.4049/jimmunol.2101076en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed35613727en_US
bordeaux.journalJournal of Immunologyen_US
bordeaux.page2663-2674en_US
bordeaux.volume208en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue12en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamSISTM_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Immunology&rft.date=2022-06-15&rft.volume=208&rft.issue=12&rft.spage=2663-2674&rft.epage=2663-2674&rft.eissn=0022-1767&rft.issn=0022-1767&rft.au=RICHERT,%20Laura&LELIEVRE,%20Jean%20Daniel&LACABARATZ,%20Christine&HARDEL,%20Lucile&HOCINI,%20Hakim&rft.genre=article


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