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High–temporal resolution profiling reveals distinct immune trajectories following the first and second doses of COVID-19 mRNA vaccines

dc.rights.licenseopenen_US
dc.contributor.authorRINCHAI, Darawan
dc.contributor.authorDEOLA, Sara
dc.contributor.authorZOPPOLI, Gabriele
dc.contributor.authorKABEER, Basirudeen Syed Ahamed
dc.contributor.authorTALEB, Sara
dc.contributor.authorPAVLOVSKI, Igor
dc.contributor.authorMAACHA, Selma
dc.contributor.authorGENTILCORE, Giusy
dc.contributor.authorTOUFIQ, Mohammed
dc.contributor.authorMATHEW, Lisa
dc.contributor.authorLIU, LI
dc.contributor.authorVEMPALLI, Fazulur Rehaman
dc.contributor.authorMUBARAK, Ghada
dc.contributor.authorLORENZ, Stephan
dc.contributor.authorSIVIERI, Irene
dc.contributor.authorCIRMENA, Gabriella
dc.contributor.authorDENTONE, Chiara
dc.contributor.authorCUCCAROLO, Paola
dc.contributor.authorGIACOBBE, Daniele Roberto
dc.contributor.authorBALDI, Federico
dc.contributor.authorGARBARINO, Alberto
dc.contributor.authorCIGOLINI, Benedetta
dc.contributor.authorCREMONESI, Paolo
dc.contributor.authorBEDOGNETTI, Michele
dc.contributor.authorBALLESTRERO, Alberto
dc.contributor.authorBASSETTI, Matteo
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHEJBLUM, Boris
ORCID: 0000-0003-0646-452X
IDREF: 189970316
dc.contributor.authorAUGUSTINE, Tracy
dc.contributor.authorVAN PANHUYS, Nicholas
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTHIEBAUT, Rodolphe
dc.contributor.authorBRANCO, Ricardo
dc.contributor.authorCHEW, Tracey
dc.contributor.authorSHOJAEI, Maryam
dc.contributor.authorSHORT, Kirsty
dc.contributor.authorFENG, Carl G.
dc.contributor.authorZUGHAIER, Susu M.
dc.contributor.authorDE MARIA, Andrea
dc.contributor.authorTANG, Benjamin
dc.contributor.authorAIT HSSAIN, Ali
dc.contributor.authorBEDOGNETTI, Davide
dc.contributor.authorGRIVEL, Jean-Charles
dc.contributor.authorCHAUSSABEL, Damien
dc.date.accessioned2023-03-13T09:51:06Z
dc.date.available2023-03-13T09:51:06Z
dc.date.issued2022-11-11
dc.identifier.issn2375-2548en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/172267
dc.description.abstractEnKnowledge of the mechanisms underpinning the development of protective immunity conferred by mRNA vaccines is fragmentary. Here, we investigated responses to coronavirus disease 2019 (COVID-19) mRNA vaccination via high–temporal resolution blood transcriptome profiling. The first vaccine dose elicited modest interferon and adaptive immune responses, which peaked on days 2 and 5, respectively. The second vaccine dose, in contrast, elicited sharp day 1 interferon, inflammation, and erythroid cell responses, followed by a day 5 plasmablast response. Both post-first and post-second dose interferon signatures were associated with the subsequent development of antibody responses. Yet, we observed distinct interferon response patterns after each of the doses that may reflect quantitative or qualitative differences in interferon induction. Distinct interferon response phenotypes were also observed in patients with COVID-19 and were associated with severity and differences in duration of intensive care. Together, this study also highlights the benefits of adopting high-frequency sampling protocols in profiling vaccine-elicited immune responses.
dc.language.isoENen_US
dc.title.enHigh–temporal resolution profiling reveals distinct immune trajectories following the first and second doses of COVID-19 mRNA vaccines
dc.typeArticle de revueen_US
dc.identifier.doi10.1126/sciadv.abp9961en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed36367935en_US
bordeaux.journalScience Advancesen_US
bordeaux.volume8en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue45en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamSISTM_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Science%20Advances&rft.date=2022-11-11&rft.volume=8&rft.issue=45&rft.eissn=2375-2548&rft.issn=2375-2548&rft.au=RINCHAI,%20Darawan&DEOLA,%20Sara&ZOPPOLI,%20Gabriele&KABEER,%20Basirudeen%20Syed%20Ahamed&TALEB,%20Sara&rft.genre=article


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