External validation of the PAGE-B score for HCC risk prediction in people living with HIV/HBV coinfection
| dc.rights.license | open | en_US |
| dc.contributor.author | SURIAL, Bernard | |
| dc.contributor.author | MENA, Adria Ramirez | |
| dc.contributor.author | ROUMET, Marie | |
| dc.contributor.author | LIMACHER, Andreas | |
| dc.contributor.author | SMIT, Colette | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | LELEUX, Olivier | |
| dc.contributor.author | MOCROFT, Amanda | |
| dc.contributor.author | VAN DER VALK, Marc | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| hal.structure.identifier | Global Health in the Global South [GHiGS] | |
| dc.contributor.author | BONNET, Fabrice | |
| dc.contributor.author | PETERS, Lars | |
| dc.contributor.author | ROCKSTROH, Jurgen K. | |
| dc.contributor.author | GUNTHARD, Huldrych F. | |
| dc.contributor.author | BERZIGOTTI, Annalisa | |
| dc.contributor.author | RAUCH, Andri | |
| dc.contributor.author | WANDELER, Gilles | |
| dc.date.accessioned | 2023-02-23T10:14:30Z | |
| dc.date.available | 2023-02-23T10:14:30Z | |
| dc.date.issued | 2023-01-20 | |
| dc.identifier.issn | 1600-0641 (Electronic) 0168-8278 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/172076 | |
| dc.description.abstractEn | BACKGROUND & AIMS: Hepatitis B virus (HBV) coinfection is common among people living with HIV (PLWH) and the most important cause of hepatocellular carcinoma (HCC). Whereas risk prediction tools for HCC exist for patients with HBV monoinfection, they have not been evaluated in PLWH. We performed an external validation of PAGE-B in people with HIV/HBV coinfection. METHODS: We included PLWH with a positive HBsAg and without HCC before starting tenofovir from four European cohorts, and estimated the predictive performance of PAGE-B on HCC occurrence over 15 years of tenofovir-containing antiretroviral therapy (ART). Model discrimination was assessed after multiple imputation using Cox regression with the prognostic index as covariate, and by calculating Harrell's c-index. Calibration was assessed by comparing cumulative incidences with the PAGE-B derivation study using Kaplan-Meier curves. RESULTS: In total, 2'963 individuals with HIV/HBV coinfection on tenofovir-containing ART were included. PAGE-B was <10 in 26.5%, 10-17 in 57.7%, and ≥18 in 15.7% of patients. Within a median follow-up of 9.6 years, HCC occurred in 68 individuals (2.58/1000 patient-years, 95% confidence interval [CI] 2.03-3.27). The regression slope of the prognostic index for developing HCC within 15 years was 0.93 (95% CI 0.61-1.25), and the pooled c-index was 0.77 (range 0.73-0.80), both indicating good model discrimination. Cumulative incidence of HCC was lower in our study compared to the derivation study. A PAGE-B cut-off of <10 had a negative predictive value for developing HCC within 5 years of 99.4%. Restricting efforts to individuals with a PAGE-B of ≥10 would spare HCC screening in 27% of individuals. CONCLUSIONS: For individuals with HIV/HBV coinfection, PAGE-B is a valid tool to determine the need for HCC screening. IMPACT AND IMPLICATIONS: Chronic hepatitis B virus (HBV) infection is the most important cause of hepatocellular carcinoma (HCC) among people living with HIV, and valid risk prediction may guide HCC screening efforts to high-risk individuals. We aimed at validating PAGE-B, a risk prediction tool that is based on age, gender, and platelets, among 2963 individuals with HIV/HBV coinfection who received tenofovir-containing antiretroviral therapy. In the present study, PAGE-B showed good discrimination, adequate calibration, and a cut-off of less than 10 had a negative predictive value for developing HCC within 5 years of 99.4%. These results indicate that PAGE-B is a simple and valid risk prediction tool to determine the need for HCC screening among people living with HIV and HBV. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Hepatitis B virus | |
| dc.subject.en | HIV infection | |
| dc.subject.en | Hepatocellular carcinoma | |
| dc.subject.en | Liver cirrhosis | |
| dc.subject.en | Liver neoplasms | |
| dc.subject.en | Risk assessment | |
| dc.subject.en | Risk prediction models | |
| dc.subject.en | Model validation | |
| dc.subject.en | Tenofovir | |
| dc.title.en | External validation of the PAGE-B score for HCC risk prediction in people living with HIV/HBV coinfection | |
| dc.title.alternative | J Hepatol | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.jhep.2022.12.029 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 36690280 | en_US |
| bordeaux.journal | Journal of Hepatology | en_US |
| bordeaux.page | 947-957 | |
| bordeaux.volume | 78 | |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 5 | |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | ANRS CO3 Aquitaine Cohort | en_US |
| bordeaux.team | GHIGS_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-04001881 | |
| hal.version | 1 | |
| hal.date.transferred | 2023-02-23T10:14:45Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
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