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Cognitive performance is associated with glomerular filtration rate in patients with chronic kidney disease: results from the CKD-REIN cohort

dc.rights.licenseopenen_US
dc.contributor.authorPEPIN, Marion
dc.contributor.authorLEVASSORT, Helene
dc.contributor.authorBOUCQUEMONT, Julie
dc.contributor.authorLAMBERT, Oriane
dc.contributor.authorALENCAR DE PINHO, Natalia
dc.contributor.authorTURINICI, Monica
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
dc.contributor.authorMETZGER, Marie
dc.contributor.authorCHEDDANI, Lynda
dc.contributor.authorFRIMAT, Luc
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorCOMBE, Christian
dc.contributor.authorFOUQUE, Denis
dc.contributor.authorLAVILLE, Maurice
dc.contributor.authorAYAV, Carole
dc.contributor.authorLIABEUF, Sophie
dc.contributor.authorJACQUELINET, Christian
dc.contributor.authorTEILLET, Laurent
dc.contributor.authorSTENGEL, Benedicte
dc.contributor.authorMASSY, Ziad A.
dc.date.accessioned2023-02-22T14:44:20Z
dc.date.available2023-02-22T14:44:20Z
dc.date.issued2023-01-24
dc.identifier.issn1468-330X (Electronic) 0022-3050 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/172062
dc.description.abstractEnBACKGROUND: Chronic kidney disease (CKD) is associated with cognitive impairment in general population. We assessed the association between kidney and cognitive functions in patients with CKD and the influence of cardiovascular (CV) risk factors, and depression on this association. METHODS: The CKD-Renal Epidemiology and Information Network cohort included 3033 patients with CKD stages 3-4, followed for 5 years. Cognitive function was assessed with the Mini-Mental State Examination (MMSE) and estimated glomerular filtration rate (eGFR) with the CKD-Epidemiology Collaboration equation-creatinin formula. Evolution of the MMSE score over time and its association with baseline eGFR were investigated with linear mixed models. We assessed the risk of incident cognitive outcome (hospitalisation or death with relevant International Classification of Disease-10 codes), with a Cox proportional hazard model. RESULTS: The mean age was 66.8, the mean eGFR was 33 mL/min/1.73 m(2) and 387 patients (13.0%) had an MMSE score below 24 at baseline. A 10 mL/min/1.73 m(2) decrement of baseline eGFR was associated with a mean MMSE decrease of 0.12 (95% CI 0.04 to 0.19) after adjustment for demographic characteristics, depression, CV risk factors and disease; but baseline eGFR was not associated with MMSE temporal evolution. HR for cognitive outcome during follow-up (median 2.01 years) associated with a 10 mL/min/1.73 m(2) decrement of baseline eGFR was 1.35 (1.07, 1.70) (p=0.01) after adjustment. CONCLUSIONS: In patients with CKD, lower eGFR was associated with worse cognitive performance and incident cognitive events, independently of demographics, CV risk factors and depression. TRIAL REGISTRATION NUMBER: NCT03381950.
dc.language.isoENen_US
dc.title.enCognitive performance is associated with glomerular filtration rate in patients with chronic kidney disease: results from the CKD-REIN cohort
dc.title.alternativeJ Neurol Neurosurg Psychiatryen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1136/jnnp-2022-330347en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed36693722en_US
bordeaux.journalJournal of Neurology, Neurosurgery and Psychiatryen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCNRS
bordeaux.institutionCHU de Bordeaux
bordeaux.institutionInstitut Bergonié
bordeaux.teamLEHA_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Neurology,%20Neurosurgery%20and%20Psychiatry&rft.date=2023-01-24&rft.eissn=1468-330X%20(Electronic)%200022-3050%20(Linking)&rft.issn=1468-330X%20(Electronic)%200022-3050%20(Linking)&rft.au=PEPIN,%20Marion&LEVASSORT,%20Helene&BOUCQUEMONT,%20Julie&LAMBERT,%20Oriane&ALENCAR%20DE%20PINHO,%20Natalia&rft.genre=article


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