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Nutritional metabolism and cerebral bioenergetics in Alzheimer's disease and related dementias

dc.rights.licenseopenen_US
dc.contributor.authorYASSINE, Hussein N.
dc.contributor.authorSELF, Wade
dc.contributor.authorKERMAN, Bilal E.
dc.contributor.authorSANTONI, Giulia
dc.contributor.authorNAVALPUR SHANMUGAM, NandaKumar
dc.contributor.authorABDULLAH, Laila
dc.contributor.authorGOLDEN, Lesley R.
dc.contributor.authorFONTEH, Alfred N.
dc.contributor.authorHARRINGTON, Michael G.
dc.contributor.authorGRAFF, Johannes
dc.contributor.authorGIBSON, Gary E.
dc.contributor.authorKALARIA, Raj
dc.contributor.authorLUCHSINGER, Jose A.
dc.contributor.authorFELDMAN, Howard H.
dc.contributor.authorSWERDLOW, Russell H.
dc.contributor.authorJOHNSON, Lance A.
dc.contributor.authorALBENSI, Benedict C.
dc.contributor.authorZLOKOVIC, Berislav V.
dc.contributor.authorTANZI, Rudolph
dc.contributor.authorCUNNANE, Stephen
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSAMIERI, Cecilia
dc.contributor.authorSCARMEAS, Nikolaos
dc.contributor.authorBOWMAN, Gene L.
dc.date.accessioned2023-02-20T10:45:29Z
dc.date.available2023-02-20T10:45:29Z
dc.date.issued2023-03
dc.identifier.issn1552-5279 (Electronic) 1552-5260 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/171995
dc.description.abstractEnDisturbances in the brain's capacity to meet its energy demand increase the risk of synaptic loss, neurodegeneration, and cognitive decline. Nutritional and metabolic interventions that target metabolic pathways combined with diagnostics to identify deficits in cerebral bioenergetics may therefore offer novel therapeutic potential for Alzheimer's disease (AD) prevention and management. Many diet-derived natural bioactive components can govern cellular energy metabolism but their effects on brain aging are not clear. This review examines how nutritional metabolism can regulate brain bioenergetics and mitigate AD risk. We focus on leading mechanisms of cerebral bioenergetic breakdown in the aging brain at the cellular level, as well as the putative causes and consequences of disturbed bioenergetics, particularly at the blood-brain barrier with implications for nutrient brain delivery and nutritional interventions. Novel therapeutic nutrition approaches including diet patterns are provided, integrating studies of the gut microbiome, neuroimaging, and other biomarkers to guide future personalized nutritional interventions.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.title.enNutritional metabolism and cerebral bioenergetics in Alzheimer's disease and related dementias
dc.title.alternativeAlzheimers Dementen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/alz.12845en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed36479795en_US
bordeaux.journalAlzheimer's and Dementiaen_US
bordeaux.page1041-1066
bordeaux.volume19
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue3
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamELEANOR_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03996880
hal.version1
hal.date.transferred2023-02-20T10:45:58Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Alzheimer's%20and%20Dementia&rft.date=2023-03&rft.volume=19&rft.issue=3&rft.spage=1041-1066&rft.epage=1041-1066&rft.eissn=1552-5279%20(Electronic)%201552-5260%20(Linking)&rft.issn=1552-5279%20(Electronic)%201552-5260%20(Linking)&rft.au=YASSINE,%20Hussein%20N.&SELF,%20Wade&KERMAN,%20Bilal%20E.&SANTONI,%20Giulia&NAVALPUR%20SHANMUGAM,%20NandaKumar&rft.genre=article


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