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Cognitive change in breast cancer patients up to 2 years after diagnosis

dc.rights.licenseopenen_US
dc.contributor.authorLANGE, Marie
dc.contributor.authorARBOGAST, Sophie
dc.contributor.authorHARDY-LEGER, Isabelle
dc.contributor.authorRIGAL, Olivier
dc.contributor.authorLE FEL, Johan
dc.contributor.authorPISTILLI, Barbara
dc.contributor.authorPETRUCCI, Jean
dc.contributor.authorLEVY, Christelle
dc.contributor.authorCAPEL, Aurelie
dc.contributor.authorCOUTANT, Charles
dc.contributor.authorMEDEAU, Laure
dc.contributor.authorLEREBOURS, Florence
dc.contributor.authorVANLEMMENS, Laurence
dc.contributor.authorBRION, Marine
dc.contributor.authorBOURBOULOUX, Emmanuelle
dc.contributor.authorBLAIN, Maxime
dc.contributor.authorBINARELLI, Giulia
dc.contributor.authorVAZ-LUIS, Ines
dc.contributor.authorGIFFARD, Benedicte
dc.contributor.authorQUEREL, Ophelie
dc.contributor.authorEVERHARD, Sibille
dc.contributor.authorANDRE, Fabrice
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCHARLES, Cecile
dc.contributor.authorDAUCHY, Sarah
dc.contributor.authorJOLY, Florence
dc.date.accessioned2023-02-16T11:38:09Z
dc.date.available2023-02-16T11:38:09Z
dc.date.issued2022-12-26
dc.identifier.issn1460-2105 (Electronic) 0027-8874 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/171974
dc.description.abstractEnBACKGROUND: Using the large nationwide CANTO cohort, we assessed cognitive functioning change after cancer treatments in a subgroup of breast cancer patients. METHODS: We included patients with newly diagnosed invasive stage I-III breast cancer enrolled in the CANTO sub-study focused on cognitive evaluation and healthy control women matched for age and education. Episodic and working memory, executive functions, processing speed, attention, self-report cognitive difficulties (SRCD), fatigue, anxiety/depression were assessed with neuropsychological tests and self-report questionnaires, before treatment (baseline), about 1 (year-1) and 2 years (year-2) after diagnosis. We used linear mixed models to study changes in cognition and tested the effect of adjuvant chemotherapy. RESULTS: We studied 276 localized breast cancer patients (62% chemotherapy (CT+)) compared to 135 healthy controls. After adjustment, patients had lower baseline working memory, processing speed and attention scores than healthy controls (p ≤ 0.001), and the difference remained significant over follow-up for working memory and processing speed. Executive function scores were similar between groups at baseline but decreased at year-1 among patients compared to healthy controls (p for change = 0.006). This decrease in CT+ patients was significant when compared to healthy controls scores (p for change < 0.001). After adjustment, SRCD were similar between breast cancer patients and healthy controls at baseline but increased in patients after treatment at year-1 (p for change = 0.002). CONCLUSIONS: Cognitive difficulties are an important concern in breast cancer patients, starting at diagnosis. Cancer treatments induce executive function decline and SRCD, which decrease over follow-up.
dc.description.sponsorshipEtude des toxicités chroniques des traitements anticancéreux chez les patientes porteuses cancer - ANR-10-COHO-0004en_US
dc.language.isoENen_US
dc.title.enCognitive change in breast cancer patients up to 2 years after diagnosis
dc.title.alternativeJ Natl Cancer Insten_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/jnci/djac240en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed36571503en_US
bordeaux.journalJNCI: Journal of the National Cancer Instituteen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamPHARES_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
hal.identifierhal-03992251
hal.version1
hal.date.transferred2023-02-16T11:38:13Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=JNCI:%20Journal%20of%20the%20National%20Cancer%20Institute&amp;rft.date=2022-12-26&amp;rft.eissn=1460-2105%20(Electronic)%200027-8874%20(Linking)&amp;rft.issn=1460-2105%20(Electronic)%200027-8874%20(Linking)&amp;rft.au=LANGE,%20Marie&amp;ARBOGAST,%20Sophie&amp;HARDY-LEGER,%20Isabelle&amp;RIGAL,%20Olivier&amp;LE%20FEL,%20Johan&amp;rft.genre=article


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