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Voluntary physical activity improves spatial and recognition memory deficits induced by post-weaning chronic exposure to a high-fat diet

dc.rights.licenseopenen_US
hal.structure.identifierUniversidad Autónoma Metropolitana [Mexico] [UAM]
dc.contributor.authorHERNANDEZ-RAMIREZ, Susana
hal.structure.identifierUniversidad Autónoma Metropolitana [Mexico] [UAM]
dc.contributor.authorSALCEDO-TELLO, Pamela
hal.structure.identifierUniversidad Nacional Autónoma de México = National Autonomous University of Mexico [UNAM]
dc.contributor.authorOSORIO-GOMEZ, Daniel
hal.structure.identifierUniversidad Nacional Autónoma de México = National Autonomous University of Mexico [UNAM]
dc.contributor.authorBERMUDEZ-RATTONI, Federico
hal.structure.identifierUniversidad Autónoma Metropolitana [Mexico] [UAM]
dc.contributor.authorPACHECO-LOPEZ, Gustavo
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorFERREIRA, Guillaume
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLAFENETRE, Pauline
IDREF: 230337236
hal.structure.identifierUniversidad Autónoma Metropolitana [Mexico] [UAM]
dc.contributor.authorGUZMAN-RAMOS, Kioko
dc.contributor.authorOBETEEN, Consortium
dc.date.accessioned2023-02-13T14:45:35Z
dc.date.available2023-02-13T14:45:35Z
dc.date.issued2022-10
dc.identifier.issn0031-9384en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/171938
dc.description.abstractEnChildhood and adolescent exposure to obesogenic environments has contributed to the development of several health disorders, including neurocognitive impairment. Adolescence is a critical neurodevelopmental window highly influenced by environmental factors that affect brain function until adulthood. Post-weaning chronic exposure to a high-fat diet (HFD) adversely affects memory performance; physical activity is one approach to coping with these dysfunctions. Previous studies indicate that voluntary exercise prevents HFD's detrimental effects on memory; however, it remains to evaluate whether it has a remedial/therapeutical effect when introduced after a long-term HFD exposure. This study was conducted on a diet-induced obesity mice model over six months. After three months of HFD exposure (without interrupting the diet) access to voluntary physical activity was provided. HFD produced weight gain, increased adiposity, and impaired glucose tolerance. Voluntary physical exercise ameliorated glucose tolerance and halted weight gain and fat accumulation. Additionally, physical activity mitigated HFD-induced spatial and recognition memory impairments. Our data indicate that voluntary physical exercise starting after several months of periadolescent HFD exposure reverses metabolic and cognitive alterations demonstrating that voluntary exercise, in addition to its known preventive effect, also has a restorative impact on metabolism and cognition dysfunctions associated with obesity. © 2022
dc.description.sponsorshipImpact neuro-cognitif de l'obésité juvénile: approches expérimentale et clinique - ANR-15-CE17-0013en_US
dc.language.isoENen_US
dc.title.enVoluntary physical activity improves spatial and recognition memory deficits induced by post-weaning chronic exposure to a high-fat diet
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.physbeh.2022.113910en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed35820628en_US
bordeaux.journalPhysiology and Behavioren_US
bordeaux.volume254en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03986293
hal.version1
hal.date.transferred2023-02-13T14:45:38Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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