Yin-Yang control of energy balance by lipids in the hypothalamus: The endocannabinoids vs bile acids case
| dc.rights.license | open | en_US |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | LEE, Thomas H. | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | COTA, Daniela | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | QUARTA, Carmelo | |
| dc.date.accessioned | 2023-02-06T13:38:20Z | |
| dc.date.available | 2023-02-06T13:38:20Z | |
| dc.date.created | 2022 | |
| dc.date.issued | 2022 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/171874 | |
| dc.description.abstractEn | Obesity is a chronic and debilitating disorder that originates from alterations in energy-sensing brain circuits controlling body weight gain and food intake. The dysregulated syntheses and actions of lipid mediators in the hypothalamus induce weight gain and overfeeding, but the molecular and cellular underpinnings of these alterations remain elusive. In response to changes in the nutritional status, different lipid sensing pathways in the hypothalamus direct body energy needs in a Yin-Yang model. Endocannabinoids orchestrate the crosstalk between hypothalamic circuits and the sympathetic nervous system to promote food intake and energy accumulation during fasting, whereas bile acids act on the same top-down axis to reduce energy intake and possibly storage after the meal. In obesity, the bioavailability and downstream cellular actions of endocannabinoids and bile acids are altered in hypothalamic neurons involved in body weight and metabolic control. Thus, the onset and progression of this disease might result from an imbalance in hypothalamic sensing of multiple lipid signals, which are possibly integrated by common molecular nodes. In this viewpoint, we discuss a possible model that explains how bile acids and endocannabinoids may exert their effects on energy balance regulation via interconnected mechanisms at the level of the hypothalamic neuronal circuits. Therefore, we propose a new conceptual framework for understanding and treating central mechanisms of maladaptive lipid action in obesity. © 2022 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM) | |
| dc.description.sponsorship | Rôle de Tbx3 dans la détermination de l'identité fonctionnelle des neurones POMC dans l'obésité - ANR-20-CE14-0046 | en_US |
| dc.description.sponsorship | Bordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043 | en_US |
| dc.description.sponsorship | Innovations instrumentales et procédurales en psychopathologie expérimentale chez le rongeur | en_US |
| dc.description.sponsorship | La signalisation des acides biliaires dans le cerveau et son rôle dans le contrôle métabolique - ANR-17-CE14-0007 | en_US |
| dc.description.sponsorship | Rôle du récepteur aux cannabinoïdes de type 1 mitochondriale dans les circuits hypothalamiques et son interaction avec la voie mTORC1 dans l'obésité. - ANR-18-CE14-0029 | en_US |
| dc.description.sponsorship | Rôle du circuit POMC-striatum ventral dans le développement de l'obésité - ANR-21-CE14-0018 | en_US |
| dc.description.sponsorship | Initiative d'excellence de l'Université de Bordeaux - ANR-10-IDEX-0003 | en_US |
| dc.language.iso | EN | en_US |
| dc.subject.en | Obesity | |
| dc.subject.en | Endocannabinoids | |
| dc.subject.en | Bile acids | |
| dc.subject.en | Hypothalamus | |
| dc.subject.en | Lipid metabolism | |
| dc.title.en | Yin-Yang control of energy balance by lipids in the hypothalamus: The endocannabinoids vs bile acids case | |
| dc.title.alternative | Biochimie | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.biochi.2022.07.006 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 35863558 | en_US |
| bordeaux.journal | Biochimie | |
| bordeaux.hal.laboratories | Neurocentre Magendie - U1215 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | Physiopathologie de l'équilibre énergétique et obésité | en_US |
| bordeaux.identifier.funderID | Conseil Régional Aquitaine | en_US |
| bordeaux.identifier.funderID | Société Française d’Endocrinologie | en_US |
| hal.identifier | hal-03975295 | |
| hal.version | 1 | |
| hal.date.transferred | 2023-02-06T13:38:23Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biochimie&rft.date=2022&rft.au=LEE,%20Thomas%20H.&COTA,%20Daniela&QUARTA,%20Carmelo&rft.genre=article |
