Mostrar el registro sencillo del ítem

dc.rights.licenseopenen_US
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorVALLEE, Monique
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorRAUX, Pierre-Louis
dc.date.accessioned2023-02-06T12:12:41Z
dc.date.available2023-02-06T12:12:41Z
dc.date.created2022
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/171871
dc.description.abstractEnSteroids and endocannabinoids are part of two modulatory systems and some evidence has shown their interconnections in several functions. Homeostasis is a common steady-state described in the body, which is settled by regulatory systems to counterbalance deregulated or allostatic set points towards an equilibrium. This regulation is of primary significance in the central nervous system for maintaining neuronal plasticity and preventing brain-related disorders. In this context, the recent discovery of the shutdown of the endocannabinoid system (ECS) overload by the neurosteroid pregnenolone has highlighted new endogenous mechanisms of ECS regulation related to cannabis-induced intoxication. These mechanisms involve a regulatory loop mediated by overactivation of the central type-1 cannabinoid receptor (CB1R), which triggers the production of its own regulator, pregnenolone. Therefore, this highlights a new process of regulation of steroidogenesis in the brain. Pregnenolone, long considered an inactive precursor of neurosteroids, can then act as an endogenous negative allosteric modulator of CB1R. The present review aims to shed light on a new framework for the role of ECS in the addictive characteristics of cannabis with the novel endogenous mechanism of ECS involving the neurosteroid pregnenolone. In addition, this new endogenous regulatory loop could provide a relevant therapeutic model in the current context of increasing recreational and medical use of cannabis. © 2022 British Society for Neuroendocrinology.
dc.language.isoENen_US
dc.subject.enNeurosteroids
dc.subject.enPregnenolone
dc.subject.enEndocannabinoid system (ECS)
dc.subject.enType-1 cannabinoid receptor (CB1R)
dc.subject.enEndocannabinoids (eCBs)
dc.subject.enNeuromodulation
dc.subject.enCannabis addiction
dc.title.enCross-talk between neurosteroid and endocannabinoid systems in cannabis addiction
dc.title.alternativeJ Neuroendocrinol.en_US
dc.typeDocument de travail - Pré-publicationen_US
dc.identifier.doi10.1111/jne.13191en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed36043319en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamPhysiopathologie et approches thérapeutiques des maladies liées au stressen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
bordeaux.identifier.funderIDMinistère de l'Enseignement Supérieur et de la Recherche Scientifiqueen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.au=VALLEE,%20Monique&RAUX,%20Pierre-Louis&rft.genre=preprint


Archivos en el ítem

Thumbnail

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem